Genetic loci associated with forced expiratory volume in 1 s (FEV1) decline in the Lung Health Study-2
| SNP | Chromosome | Position | Alleles (coded/ noncoded) | Coded allele frequency % | SNP effect# | Treatment effect¶ | SNP × treatment+ | |||
| β mL·year−1 | p-value | β mL·year−1 | p-value | β mL·year−1 | p-value | |||||
| rs10057473 | 5 | 142887378 | G/C | 44.3 | −12.7 | 2.8×10−2 | −19.1 | 3.9×10−2 | 18.6 | 2.4×10−2 |
| rs111720447 | 7 | 68703305 | C/A | 95.2 | −29.5 | 1.8×10−2 | −168.3 | 4.1×10−6 | 86.6 | 4.8×10−6 |
| rs10108679 | 8 | 2179372 | G/C | 43.9 | −17.6 | 5.3×10−3 | −38.1 | 5.3×10−5 | 41.1 | 3.1×10−6 |
| rs1361249 | 10 | 7007283 | C/T | 70.1 | 24.5 | 5.8×10−5 | 55.8 | 4.1×10−5 | −42.6 | 1.7×10−6 |
| rs117989968 | 11 | 128639945 | T/C | 97.8 | 126.1 | 3.0×10−6 | 338.0 | 4.1×10−6 | −173.4 | 3.2×10−6 |
| rs12433619 | 14 | 71679203 | A/G | 48.2 | 21.4 | 2.3×10−4 | 34.6 | 4.3×10−4 | −38.7 | 2.5×10−6 |
Given that the overall slope of FEV1 change was negative, for the single nucleotide polymorphism's (SNP) main effect, a positive β estimate indicates less (or a slower) decline and a negative β estimate indicates more (or an accelerated) decline. #: SNP main effect; ¶: treatment main effect (triamcinolone versus placebo); +: SNP–treatment interaction effect.