TABLE 3

Positivity to TST and IGRA test and LTBI estimation

ABCDEF
Total#
N
TST-positive
n (% A)
TST-positive at second-level screening
n (% B)
IGRA-positive
n (% C)
Estimated LTBI cases+
n (% A)
Literature estimates for LTBI prevalence§
%
Total52552259 (43.0)1302 (57.6)844 (64.8)1464 (27.9)-
Geographical region and country of origin
 West Africa23801153 (48.4)741 (64.3)480 (64.8)747 (31.4)19
  Guinea327178 (54.4)90 (50.6)62 (68.9)123 (37.6)22
  Nigeria562217 (38.6)149 (68.7)100 (67.1)146 (26.0)18
 East Africa1124448 (39.9)212 (47.3)176 (83.0)372 (33.1)22
  Eritrea572182 (31.8)62 (34.1)49 (79.0)144 (25.2)7
  Somalia454221 (48.7)126 (57.0)110 (87.3)193 (42.5)22
 Asia1213465 (38.3)291 (62.6)141 (48.5)225 (18.6)27
  Bangladesh384192 (50.0)124 (64.6)48 (38.7)74 (19.3)28
  Pakistan383156 (40.7)90 (57.7)54 (60.0)94 (24.5)29
 Other408133 (32.6)58 (43.6)47 (81.0)108 (26.5)-
 Unknown13068 (52.3)----
WHO region of origin
 WHO AFR36971688 (45.7)997 (59.1)693 (69.5)1173 (31.7)22
 WHO EMR987294 (29.8)166 (56.5)97 (58.4)172 (17.4)16
 Other441217 (49.2)139 (64.1)54 (38.8)84 (19.0)-
 Unknown13068 (52.3)----

Missing data for one or more variables are collected as “unknown”, except for missing result for TST. TST: tuberculin skin test; IGRA: interferon-γ release assay; LTBI: latent tuberculosis infection; WHO: World Health Organization; WHO AFR: WHO African Region; WHO EMR: WHO Eastern Mediterranean Region. #: the total number of individuals (A) was calculated as the total number of subjects who underwent TST minus those with active TB; : second-level screening included both chest radiography and IGRA testing, performed at the Villa Marelli Institute; +: the estimated prevalence of LTBI (E) was calculated using the % of IGRA-positive people among the TST-positive people who underwent further testing with IGRA at the Villa Marelli Institute (D/C) applied to the number of those lost between TST and IGRA evaluations (×(B−C)), and assuming they had the same level of positivity as those tested with IGRA. This figure was then added to those with a positive IGRA test (D) to derive the numerator; §: literature estimates are taken from Houben and Dodd [29].