European versus Japanese balloon pulmonary angioplasty (BPA)

French reference centreHannover and Bad NauheimJapanese multicentre registry
Total patients n18456308
Age years63±1465 (55–74)62±13
Females %496180
Total procedures performed n10062661408
Procedures per person5 (median)5 (median)4 (median)
BaselineAfter BPABaselineAfter BPABaselineAfter BPA
Patients n1545655308196
6MWD m396±120441±104358±108391±108318±122430±109
mPAP mmHg43.9±9.531.6±9.040±1233±1143.2±11.022.5±5.4
PaO2 mmHg65.0±9.073.3±12.062.0±9.066.0±10.0Not statedNot stated
SaO2 %Not statedNot stated93.0±3.094.0±3.093.3±4.594.0±5.2
CO L·min−14.8±1.25.6±1.44.4±1.14.6±1.2Not statedNot stated
CI L·min−1·m−22.7±0.63.1±0.82.4±0.62.5±0.62.6±0.82.8±0.6
PVR dyn·s·cm−5604±226329±177591±286440±279854±450288±195
Patients on riociguat and/or drugs approved for PAH %62Not stated92Not stated7245
Lung injury (% of sessions)9.19.417.8
30-day mortality %
  • Data are presented as mean±sd or median (interquartile range), unless stated otherwise. 6MWD: 6-min walk distance; mPAP: mean pulmonary artery pressure; PaO2: arterial oxygen tension; SaO2: arterial oxygen saturation; CO: cardiac output; CI: cardiac index; PVR: pulmonary vascular resistance; PAH: pulmonary arterial hypertension.