TABLE 1

Number of patients with tuberculosis (TB) disease as the cause of death (CoD), with concomitant TB disease and with Mycobacterium tuberculosis detection at death by study group and among HIV-positive cases.

AutopsiesTB as CoD#Concomitant TBTotal
M. tuberculosis DNA detection+Total cases with TB findings§
All autopsies
 Children543 (5.6)8 (14.8)11 (20.4)3 (5.6)14 (25.9)
 Maternal deaths575 (8.8)5 (8.8)10 (17.5)5 (8.8)15 (26.3)
 Adults11223 (20.5)18 (16.1)41 (36.6)10 (8.9)51 (45.5)
 Total22331 (13.9)31 (13.9)62 (27.8)18 (8.1)80 (35.9)
Autopsies among HIV-positive cases
 Childrenƒ170 (0.0)3 (17.6)3 (17.6)0 (0.0)3 (17.6)
 Maternal deaths365 (13.9)4 (11.1)9 (25.0)5 (13.9)14 (38.9)
 Adults7318 (24.7)13 (17.8)31 (42.5)6 (8.2)37 (50.7)
 Total12623 (18.3)20 (15.9)43 (34.1)11 (8.7)54 (42.9)

Data are presented as n or n (%). #: HIV status of two cases could not be ascertained; : when review of the entire complete diagnostic autopsy (CDA) (including histological, microbiological and clinical data) following a previously described algorithm of CoD determination deemed TB to be the CoD. This definition required the presence of histological TB-compatible lesions and microbiological confirmation of TB by molecular assays; +: when histological lesions compatible with TB were present at death, but review of the CDA deemed another disease to be the most likely cause. This definition required the presence of histological TB-compatible lesions and microbiological confirmation of TB by molecular assays; §: attributed when both TB-PCR and Xpert Ultra were positive in the absence of compatible histological findings; ƒ: all cases in which TB disease was found at death (as the cause of death or as a concomitant finding) and cases in which only M. tuberculosis DNA were detected.