Definition of haemodynamic instability, which delineates acute high-risk pulmonary embolism (one of the following clinical manifestations at presentation)

(1) Cardiac arrest(2) Obstructive shock [6870](3) Persistent hypotension
Need for cardiopulmonary resuscitationSystolic BP <90 mmHg or vasopressors required to achieve a BP ≥90 mmHg despite adequate filling statusSystolic BP <90 mmHg or systolic BP drop ≥40 mmHg, lasting longer than 15 min and not caused by new-onset arrhythmia, hypovolaemia, or sepsis
End-organ hypoperfusion (altered mental status; cold, clammy skin; oliguria/anuria; increased serum lactate)

BP: blood pressure.