Findings related to the acute PE event (obtained at PE diagnosis) | Concomitant chronic diseases and conditions predisposing to CTEPH (documented at PE diagnosis or at 3–6 month follow-up) |
Previous episodes of PE or DVT | Ventriculo-atrial shunts |
Large pulmonary arterial thrombi on CTPA | Infected chronic i.v. lines or pacemakers |
Echocardiographic signs of PH/RV dysfunctiona | History of splenectomy |
CTPA findings suggestive of pre-existing chronic thromboembolic diseaseb | Thrombophilic disorders, particularly antiphospholipid antibody syndrome and high coagulation factor VIII levels |
Non-O blood group | |
Hypothyroidism treated with thyroid hormones | |
History of cancer | |
Myeloproliferative disorders | |
Inflammatory bowel disease | |
Chronic osteomyelitis |
CTEPH: chronic thromboembolic pulmonary hypertension; CTPA: computed tomographic pulmonary angiography; DVT: deep vein thrombosis; i.v.: intravenous; LV: left ventricular; PE: pulmonary embolism; PH: pulmonary hypertension; RV: right ventricular. aEchocardiographic criteria of RV dysfunction are graphically presented in Figure 3, and their prognostic value summarized in supplementary table 3. On CTPA (four-chamber views of the heart), RV dysfunction is defined as RV/LV diameter ratio >1.0. bDirect and indirect vascular signs, as well as lung parenchymal findings, are summarized in supplementary table 2.