Comparison between participants with chronic obstructive pulmonary disease with or without bronchodilator reversibility
| ΔFEV1 | ΔFVC | |||||
| <12% | ≥12% | p-value | <10.5% | ≥10.5% | p-value | |
| Subjects n | 865 | 281 | 833 | 280 | ||
| Wheeze | 37.3 | 52.0 | <0.0001 | 40.2 | 45.0 | 0.16 |
| Wheeze and breathlessness | 15.3 | 30.6 | <0.0001 | 17.2 | 25.7 | 0.002 |
| Wheeze when no cold | 17.2 | 28.8 | <0.0001 | 18.8 | 24.3 | 0.047 |
| Habitual coughing | 39.3 | 47.0 | 0.02 | 40.6 | 44.3 | 0.28 |
| Chronic bronchitis | 18.7 | 26.2 | 0.007 | 18.8 | 26.3 | 0.008 |
| Exacerbations | 0.008 | 0.13 | ||||
| 0 | 94.9 | 89.6 | 94.3 | 91.0 | ||
| 1 | 1.4 | 2.3 | 1.3 | 2.8 | ||
| ≥2 | 3.7 | 8.1 | 4.5 | 6.3 | ||
| mMRC score | <0.0001 | 0.001 | ||||
| 0 | 60.4 | 43.5 | 58.9 | 46.2 | ||
| 1 | 24.6 | 31.3 | 25.8 | 29.4 | ||
| 2 | 4.3 | 4.9 | 4.4 | 5.5 | ||
| 3 or 4 | 10.6 | 20.3 | 10.9 | 18.9 | ||
| SF-12# | ||||||
| MCS-12 | 50.5±10.2 | 49.2±11.0 | 0.12 | 50.5±10.0 | 49.6±11.3 | 0.32 |
| PCS-12 | 45.1±10.2 | 42.2±11.0 | 0.0006 | 45.0±10.2 | 42.6±11.1 | 0.005 |
Data are presented as % or mean±sd, unless otherwise stated. FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; mMRC: modified Medical Research Council; SF-12: 12-item short form questionnaire; MCS: mental health component score; PCS: physical component score. #: n=839.