Determinants of bronchodilator reversibility in subjects with chronic obstructive pulmonary disease
| ΔFEV1 | ΔFVC | |||
| ≥12% | ≥12% + 200 mL | ≥10.5% | ≥10.5% + 320 mL | |
| Female | 1.30 (0.92–1.84) | 0.88 (0.61–1.28) | 1.21 (1.04–1.40) | 1.15 (0.99–1.33) |
| Age | 1.10 (0.94–1.28) | 0.95 (0.81–1.11) | 1.61 (1.16–2.23) | 1.11 (0.79–1.56) |
| Current smoking | 0.97 (0.69–1.35) | 0.93 (0.66–1.31) | 1.14 (0.82–1.58) | 1.03 (0.74–1.43) |
| BMI kg·m−2 | ||||
| <20 | 0.65 (0.41–1.04) | 0.53 (0.32–0.90) | 0.82 (0.52–1.29) | 0.75 (0.47–1.21) |
| 20–25 | 1 | 1 | 1 | 1 |
| >25–30 | 1.32 (0.90–1.92) | 1.30 (0.89–1.90) | 1.19 (0.83–1.71) | 1.14 (0.79–1.64) |
| >30 | 1.30 (0.82–2.07) | 1.27 (0.80–2.03) | 1.46 (0.94–2.27) | 1.42 (0.91–2.21) |
| Wheeze | 1.23 (0.90–1.70) | 1.21 (0.88–1.68) | 0.89 (0.65–1.20) | 0.98 (0.72–1.34) |
| Wheeze and breathlessness | 1.41 (0.98–2.03) | 1.31 (0.90–1.91) | 1.06 (0.74–1.52) | 1.16 (0.80–1.67) |
| Wheeze when no cold | 1.43 (0.99–2.06) | 1.56 (1.08–2.26) | 1.10 (0.77–1.57) | 1.17 (0.81–1.69) |
| Habitual coughing | 1.06 (0.77–1.45) | 0.97 (0.69–1.34) | 0.92 (0.68–1.25) | 0.94 (0.69–1.28) |
| Chronic bronchitis | 1.01 (0.70–1.47) | 0.95 (0.64–1.39) | 1.20 (0.85–1.70) | 1.29 (0.91–1.84) |
| Exacerbations | ||||
| 0 | 1 | 1 | 1 | 1 |
| 1 | 0.94 (0.30–2.90) | 0.88 (0.26–2.96) | 1.38 (0.49–3.91) | 1.53 (0.53–4.37) |
| ≥2 | 1.16 (0.58–2.30) | 0.65 (0.30–1.39) | 0.87 (0.44–1.73) | 1.04 (0.52–4.37) |
| mMRC score | ||||
| 0 | 1 | 1 | 1 | 1 |
| 1 | 1.10 (0.75–1.63) | 1.13 (0.76–1.67) | 0.98 (0.67–1.42) | 0.96 (0.65–1.42) |
| 2 | 0.70 (0.31–1.56) | 0.67 (0.29–1.57) | 0.91 (0.43–1.93) | 0.71 (0.32–1.60) |
| 3 or 4 | 0.84 (0.51–1.39) | 0.69 (0.40–1.17) | 0.99 (0.61–1.61) | 1.02 (0.62–1.67) |
| SF-12# | ||||
| MCS-12 | 0.99 (0.97–1.004) | 0.99 (0.98–1.01) | 1.00 (0.99–1.02) | 0.99 (0.98–1.01) |
| PCS-12 | 1.01 (0.99–1.03) | 1.01 (0.99–1.02) | 0.99 (0.98–1.01) | 1.01 (0.99–1.03) |
| Pre-bronchodilator FEV1 % pred | 0.94 (0.93–0.95) | 0.96 (0.95–0.97) | 0.96 (0.95–0.97) | 0.97 (0.96–0.98) |
| Pre-bronchodilator FVC % pred | 0.96 (0.95–0.97) | 0.98 (0.97–0.98) | 0.95 (0.94–0.96) | 0.96 (0.96–0.97) |
Data are presented as OR (95% CI), adjusted by sex, age, body mass index (BMI), smoking, pre-bronchodilator forced expiratory volume in 1 s (FEV1) and study. Statistically significant associations are presented in bold. FVC: forced vital capacity; mMRC: modified Medical Research Council; SF-12: 12-item short form questionnaire; MCS: mental health component score; PCS: physical component score.