Baseline characteristics and response to pulmonary rehabilitation in patients with interstitial lung disease#

BaselineResponse to pulmonary rehabilitation (95% CI)p-value
Age years70±10
FVC L2.2±0.80.0 (−0.1–0.0)0.06
FVC % pred71.9±21.5−1.1 (−2.9–0.7)0.22
MRC Dyspnoea score3.2±1.1−0.7 (−0.8– −0.5)<0.01
BMI kg·m−228.5±6.00.0 (−0.1–0.1)0.51
Smoking status
 Current smoker2
 Long-term oxygen therapy7
 Ambulatory oxygen therapy14
ISWT distance m276±16463 (52–74)<0.01
KBILD score
 KBILD-Psychological55.7±16.15.9 (4.1–7.8)<0.01
 KBILD-Breathlessness and activities39.2±15.85.7 (4.0–7.4)<0.01
 KBILD-Chest symptoms62.7±22.46.0 (3.5–8.4)<0.01
 KBILD-Total54.3±10.84.2 (3.0–5.3)<0.01
CRQ score
 CRQ-Dyspnoea15.3±5.54.7 (3.9–5.4)<0.01
 CRQ-Fatigue14.4±5.12.3 (1.7–5.8)<0.01
 CRQ-Emotion31.6±9.13.2 (2.3–4.2)<0.01
 CRQ-Mastery18.6±5.41.8 (1.2–2.4)<0.01
 CRQ-Total80.0±20.712.0 (9.8–14.2)<0.01

Baseline data are reported as % or mean±sd, unless otherwise stated. FVC: forced vital capacity; MRC: Medical Research Council; BMI: body mass index; ISWT: incremental shuttle walk test; KBILD: King's Brief Interstitial Lung Disease; CRQ: Chronic Respiratory Questionnaire. #: n=209; : a positive change in ISWT, KBILD (domain and total scores) and CRQ (domain and total scores) is associated with improvement, whereas a negative change in MRC Dyspnoea is associated with improvement.