TABLE 1

Unit costs

	Unit cost EUR	Source
Study medications, per dose
Alteplase 10 mg	164	British National Formulary
Pulmozyme 2.5 mg	19	British National Formulary
Initial hospital stays, per day
Initial stay, nonsurgery	502	NHS Reference Costs
Initial stay, surgery	955	NHS Reference Costs
Subsequent admissions
Hospital stay^#	756^#	NHS Reference Costs

Individual hospitalisation costs were applied in the main analysis. Based on the British National Formulary (www.bnf.org) and NHS Reference Costs [21]. ^#: weighted average for the 37 different reasons patients were readmitted during study follow-up.