TABLE 2

Associations between computed tomography (CT) and bronchoalveolar lavage (BAL) measures

	%Disease		%Bronchiectasis		%TrappedAir
	Coefficient (95% CI)	p-value	Coefficient (95% CI)	p-value	Coefficient (95% CI)	p-value
Age	0.54 (0.46–0.63)	<0.001	0.14 (0.10–0.19)	<0.001	0.69 (0.41–0.97)	<0.001
NE activity	1.27 (0.89–1.64)	<0.001	0.47 (0.29–0.64)	<0.001	5.24 (3.98–6.50)	<0.001
IL-8 (log)	0.30 (0.20–0.40)	<0.001	0.05 (0.00–0.09)	0.035	0.94 (0.61–1.27)	<0.001
Infection^#	0.65 (0.28–1.01)	<0.001	0.09 (−0.08–0.26)	0.282	2.84 (1.57–4.12)	<0.001
Previous NE activity detections^¶	0.31 (0.09–0.54)	0.007	0.13 (0.01–0.25)	0.029	1.45 (0.69–2.20)	<0.001
Previous IL-8 detections^¶	0.19 (−0.01–0.39)	0.069	0.05 (−0.05–0.15)	0.327	0.64 (−0.03–1.30)	0.060
Previous infection detections^¶	0.23 (−0.01–0.47)	0.060	0.16 (0.04–0.28)	0.011	0.65 (−0.16–1.46)	0.117

Linear mixed model data between CT and BAL measures of infection and inflammation. Age is included as a fixed effect in each model, and random intercepts and slopes for each patient. NE: neutrophil elastase; IL-8: interleukin-8. ^#: detection of significant colonisation of a pro-inflammatory pathogen; ^¶: number of detections of NE and any pro-inflammatory infection detections in annual surveillance BALs performed prior to the CT scan.