CpG¶ | Locus | ACME | ADE | Total effect | Proportion | ||||
Estimate (95% CI) | p-value | Estimate (95% CI) | p-value | Estimate (95% CI) | p-value | Estimate (95% CI) | p-value | ||
cg01940273 | ALPPL2 | −0.0079 (−0.0119– −0.0041) | <0.0001 | −0.0026 (−0.0129–0.0077) | 0.604 | −0.0106 (−0.0203– −0.0014) | 0.026 | 0.7313 (0.2616–3.4325) | 0.026 |
cg03636183 | F2RL3 | −0.0080 (−0.0122– −0.0040) | <0.0001 | −0.0029 (−0.0126–0.0062) | 0.556 | −0.0108 (−0.0197– −0.0021) | 0.018 | 0.7312 (0.2819–2.9097) | 0.018 |
cg05575921 | AHRR | −0.0102 (−0.0147– −0.0055) | <0.0001 | −0.0008 (−0.0109–0.0086) | 0.870 | −0.0110 (−0.0202– −0.0020) | 0.012 | 0.9213 (0.3818–4.0453) | 0.012 |
cg05951221 | ALPPL2 | −0.0075 (−0.0122– −0.0030) | 0.002 | −0.0033 (−0.0131–0.0062) | 0.520 | −0.0109 (−0.0197– −0.0022) | 0.020 | 0.6836 (0.1942–2.7656) | 0.022 |
cg06126421 | IER3 | −0.0054 (−0.0093– −0.0017) | <0.0001 | −0.0049 (−0.0148–0.0049) | 0.328 | −0.0103 (−0.0194– −0.0012) | 0.030 | 0.5233 (0.1050–2.5558) | 0.030 |
cg09935388 | GFI1 | −0.0033 (−0.0058– −0.0010) | 0.002 | −0.0073 (−0.0168–0.0022) | 0.122 | −0.0105 (−0.0198– −0.0013) | 0.034 | 0.3009 (0.0568–1.4190) | 0.036 |
cg21161138 | AHRR | −0.0056 (−0.0089– −0.0025) | <0.0001 | −0.0052 (−0.0146–0.0043) | 0.282 | −0.0108 (−0.0194– −0.0020) | 0.020 | 0.5127 (0.1647–2.0961) | 0.020 |
cg21566642 | ALPPL2 | −0.0098 (−0.0145– −0.0057) | <0.0001 | −0.0014 (−0.0116–0.0089) | 0.796 | −0.0112 (−0.0209– −0.0011) | 0.024 | 0.8663 (0.3453–4.6567) | 0.024 |
cg22994830 | PRKAR1B | −0.0002 (−0.0009–0.0003) | 0.542 | −0.0103 (−0.0201– −0.0010) | 0.028 | −0.0105 (−0.0202– −0.0013) | 0.024 | 0.0103 (−0.0470–0.1595) | 0.550 |
cg24859433 | IER3 | −0.0024 (−0.0053–0.0002) | 0.068 | −0.0082 (−0.0179–0.0013) | 0.112 | −0.0107 (−0.0201– −0.0014) | 0.022 | 0.2186 (−0.0438–1.2776) | 0.090 |
ACME: average causal mediation effect; ADE: average direct effect. For analogous results for FEV1 and FVC, see supplementary table S22. #: performed using the R package mediation [17]. ¶: previously reported candidate CpG for mediation of effect of smoking on lung function [4].