TABLE 1

Differences in post-transplant complications between the recipient groups

Post-transplant complicationAATDCOPDOutcome (death AATD/COPD)p-value
Total recipients1428
Associated with NE activity
 Anastomotic complication4 (2 Z0, 1 ZZ, 1 MZ)02/00.01
 Other tissue fragility1 (ZZ)11/00.33
 Bowel ischaemia3 (3 ZZ)02/00.03
 Liver steatosis pre-transplant3 (ZZ)20/00.31
 Liver cirrhosis post-transplant1 (ZZ)00/00.33
Common complication
 Acute rejection010/1>0.9
 CLAD040/10.28
 Sepsis1 (NA)41/40.65
 Lung cancer2 (1 ZZ, 1 NA)40/3>0.9
 PTLD010/1>0.9
 Other malignancy1 (ZZ)10/0>0.9
 Heart failure010/1>0.9

Some patients had more than one complication but one primary cause of death was chosen. p-values in bold are statistically significant. AATD: alpha-1 antitrypsin deficiency; COPD: chronic obstructive pulmonary disease; NE: neutrophil elastase; CLAD: chronic lung allograft dysfunction; PTLD: post-transplant lymphoproliferative disorders.