TABLE 2

Capsaicin dose thresholds with and without self-attempted cough suppression during tussive challenge tests in participants with chronic refractory cough and healthy controls

	Chronic refractory cough	Healthy controls	p-value^#
With self-attempted cough suppression
Subjects	30	23
CS1 µmol·L⁻¹	2.01±3.40	40.34±6.64	<0.0001
CS2 µmol·L⁻¹	2.52±3.44	71.52±6.06	<0.0001
CS5 µmol·L⁻¹	4.94±4.43	261.10±4.34	<0.0001
Without self-attempted cough suppression
Subjects	11	13
C1 µmol·L⁻¹	0.91±5.17	7.20±2.82	0.0012
C2 µmol·L⁻¹	1.31±4.89	11.44±2.82	0.0015
C5 µmol·L⁻¹	3.86±5.13	45.89±3.95	0.0004

Data presented as n or geometric mean±sd, unless otherwise stated. CS1, CS2, CS5: capsaicin concentrations to elicit one, two and five coughs, respectively, during self-attempted suppression of coughing; C1, C2, C5: capsaicin concentrations to elicit one, two and five coughs, respectively, without self-attempted cough suppression. ^#: Mann–Whitney U-test.