TABLE 3

Results of logistic regression analysis for respiratory insufficiency (n=765)

CharacteristicUnivariate analysisMultivariate analysis
OR (95% CI)p-valueOR (95% CI)p-value
Age at diagnosis per decade1.49 (1.31–1.70)<0.0011.13 (0.96–1.32)0.14
Male sex0.90 (0.67–1.21)0.50
Ethnicity
 Caucasian
 African-american1.45 (0.83–2.55)0.19
 Other1.39 (0.78–2.47)0.27
BMI class kg·m−2
 <18.53.29 (1.46–7.41)0.004
 18.5–24.9
 25–29.90.74 (0.53–1.04)0.08
 ≥300.82 (0.55–1.22)0.33
Diagnosis delay per year0.93 (0.84–1.01)0.090.77 (0.67–0.88)<0.001
El Escorial criteria
 Definite ALS
 Possible ALS0.4 (0.26–0.61)<0.001
 Probable ALS0.38 (0.25–0.58)<0.001
 Suspected ALS0.29 (0.19–0.46)<0.001
Symptom onset site
 Limb
 Bulbar1.62 (1.15–2.30)0.0061.70 (1.08–2.67)0.02
FVC per 10% decrease2.65 (2.30–3.06)<0.0012.36 (2.04–2.74)<0.001
ALSFRS-R total score per 6 decrease2.12 (1.80–2.50)<0.0011.59 (1.29–1.95)<0.001
ALSFRS-R dyspnoea score
 >2
 ≤24.67 (2.98–7.31)<0.0011.82 (1.02–3.26)0.04
ALSFRS-R orthopnoea score
 >2
 ≤27.29 (3.89–13.65)<0.001
Smoking history
 Never
 Previous1.33 (0.98–1.82)0.07
 Current0.87 (0.52–1.47)0.603
Coronary artery disease1.73 (1.06–2.83)0.03
Diabetes mellitus2.8 (1.74–4.50)<0.001
Hypertension1.57 (1.16–2.11)0.003

BMI: body mass index; ALS: amyotrophic lateral sclerosis; FVC: forced vital capacity; ALSFRS-R: amyotrophic lateral sclerosis functional rating scale-revised.