TABLE 5

Baseline characteristics of the Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) cohort (n=7083)

CharacteristicResult
Age at diagnosis years56±12
Male sex4371 (62)
Ethnicity
 Caucasian6763 (96)
 African-american106 (1)
 Other214 (3)
BMI class kg·m−2
 <18.5464 (7)
 18.5–24.93060 (43)
 25–29.92376 (33)
 ≥301183 (17)
Diagnosis delay years0.8 (0.4–1.3)
Symptom onset site
 Limb5517 (78)
 Bulbar1566 (22)
FVC % predicted88±20
ALSFRS-R total score37±6
ALSFRS-R dyspnoea score
 44887 (69)
 31133 (16)
 2779 (11)
 1213 (3)
 071 (1)
ALSFRS-R orthopnoea score
 45902 (84)
 3708 (10)
 2334 (5)
 171 (1)
 048 (<1)

Data are presented as n (%), mean±sd or median (interquartile range). BMI: body mass index; FVC: forced vital capacity; ALSFRS-R: amyotrophic lateral sclerosis functional rating scale-revised.