TABLE 3

Fold change of mRNA expression in lungs of steroid-treated mice

Control groupTDI groupTDI+prednisone groupTDI+fluticasone propionate group
Ccl111.00±0.267.85±2.22**7.21±2.276.28±2.52
Clca31.00±0.1241.45±8.52**47.30±11.9535.32±19.47
Cxcl11.00±0.148.37±2.99**7.57±2.548.97±3.36
Cxcl31.00±0.254.30±1.17**7.06±3.647.50±3.65
Csf31.00±0.3518.15±4.22**32.99±12.7132.91±11.33
Il17a1.00±0.4228.71±4.68**33.59±5.7835.18±5.65
Il17f1.00±0.092.61±0.72*2.68±0.762.12±0.46

mRNA expression was normalised to control values; data are presented as mean±sd fold change. *: p<0.05; **: p<0.01, compared with the control group. No significant differences were observed between the toluene diisocyanate (TDI) group and the TDI+prednisone group or between the TDI group and the TDI+fluticasone propionate group.