TABLE 1

Research questions from the World Health Organization (WHO) tuberculosis (TB) policy guidance documents

Policy guidanceResearch questions
1. Early detection of TB3
 1.1 Systematic screening for active tuberculosis: principles and recommendations3
2. Diagnosing TB disease35
 2.1 Xpert MTB/RIF and Ultra assays for the diagnosis of pulmonary and extrapulmonary TB in adults and children and WHO Meeting Report of a Technical Expert Consultation: non-inferiority analysis of Xpert MTB/RIF Ultra compared to Xpert MTB/RIF12
 2.2 The use of loop-mediated isothermal amplification (TB-LAMP) for the diagnosis of pulmonary tuberculosis5
 2.3 The use of lateral flow urine lipoarabinomannan assay (LF-LAM) for the diagnosis and screening of active tuberculosis in people living with HIV: policy update7
 2.4 The use of molecular line probe assays for the detection of resistance to isoniazid and rifampicin5
 2.5 Molecular line probe assays for the detection of resistance to second-line anti-tuberculosis drugs: policy guidance6
3. Diagnosing and treating latent TB infection10
4. Treating TB38
 4.1 Treatment of drug-susceptible tuberculosis and patient care: 2017 update8
 4.2 WHO treatment guidelines for isoniazid-resistant TB12
 4.3 WHO treatment guidelines for drug-resistant tuberculosis: 2016 update18
5. TB/HIV and other comorbidities38
 5.1 Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection (this is an HIV guideline and the two research questions were those relevant to TB)2
 5.2 Integrating collaborative TB and HIV services within a comprehensive package of care for people who inject drugs: consolidated guidelines19
 5.3 WHO policy on collaborative TB/HIV activitiesSee ref. [9]
 5.4 Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy (this is an HIV guideline and the 4 research questions were those relevant to TB)4
 5.5 Nutritional care and support for patients with tuberculosis13
6. Managing TB in children31
 6.1 Guidance for national tuberculosis programmes on the management of tuberculosis in children31

All guidelines are accessible through the WHO Compendium of TB Guidelines and Associated Standards [7], also available as a mobile phone app.