TABLE 5

Associations between Aspergillus and clinical and radiological findings

All patientsAspergillus-specific IgG-positiveAspergillus-specific IgG-negativep-valueOR (95% CI)CPA presentCPA absentp-valueOR (95% CI)
Symptomsn=285n=28n=257n=14n=271
 Cough#94 (33.0)15 (53.6)79 (30.7)0.0152.60 (1.18–5.72)11 (78.6)83 (30.6)<0.0018.30 (2.26–30.55)
 Haemoptysis#21 (7.4)8 (28.6)13 (5.1)<0.0017.51 (2.78–20.24)7 (50.0)14 (5.2)<0.00118.36 (5.65–59.60)
 Fatigue89 (31.2)9 (32.1)80 (31.1)0.9121.05 (0.45–2.42)6 (42.9)83 (30.6)0.3361.70 (0.57–5.05)
 Fevers26 (9.1)3 (10.7)23 (8.9)0.7291.22 (0.34–4.35)2 (14.3)24 (8.9)0.3711.71 (0.36–8.12)
 Night sweats51 (17.9)6 (21.4)45 (17.5)0.6071.25 (0.49–3.35)4 (28.6)47 (17.3)0.2871.91 (0.57–6.34)
 Chest pain76 (26.7)11 (39.3)65 (25.3)0.1121.91 (0.85–4.29)7 (50.0)69 (25.5)0.062.93 (0.99–8.64)
Chest radiography (resurvey)n=285n=28n=257n=14n=271
 Cavitation50 (17.5)17 (60.7)33 (12.8)<0.00110.49 (4.52–23.34)12 (85.7)38 (14.0)<0.00136.79 (7.92–170.87)
 Fungal ball13 (4.6)5 (17.9)8 (3.1)<0.0016.77 (2.05–22.38)4 (28.6)9 (3.3)0.00211.64 3.06–44.31
 Paracavitary fibrosis36 (12.6)7 (25.0)29 (11.3)0.0382.62 (1.02–6.7)4 (28.6)32 (11.8)0.0852.99 (0.88–10.09)
 Pleural thickening50 (17.5)16 (57.1)34 (13.2)<0.0018.74 (3.81–20.07)10 (71.4)40 (14.8)<0.00114.44 (4.32–48.28)
Chest radiography progressionn=285n=28n=257n=14n=271
 Cavitation7 (2.5)4 (14.3)3 (1.2)0.00214.06 (2.97–66.51)1 (7.1)6 (2.2)0.3013.38 (0.38–30.21)
 Fungal ball7 (2.5)3 (10.7)4 (1.6)0.0237.56 (1.60–35.70)2 (14.3)5 (1.8)0.0418.83 (1.55–50.27)
 Paracavitary fibrosis18 (6.3)5 (17.9)13 (5.1)0.0084.06 (1.33–12.41)3 (21.4)15 (5.5)0.054.64 (1.17–18.41)
 Pleural thickening16 (5.6)5 (17.9)11 (4.3)0.0034.84 (1.55–15.14)3 (21.4)13 (4.8)0.0375.39 (1.34–21.71)
 Any progressive change34 (11.9)12 (42.9)22 (8.6)<0.0018.01 (3.37–19.06)7 (50.0)27 (10.0)<0.0019.04 (2.95–27.71)
CT of the thoraxn=73n=21n=52n=14n=59
 Fungal ball#11 (15.1)9 (42.9)2 (3.8)<0.00118.75 (3.58–98.28)9 (64.3)2 (3.4)<0.00151.3 (8.61–305.47)
 Cavitation35 (47.9)16 (76.2)19 (36.5)0.0025.56 (1.76–17.59)14 (100)21 (35.6)<0.001
 Paracavitary fibrosis#28 (38.4)16 (76.2)12 (23.1)<0.00110.67 (3.23–35.19)14 (100)14 (23.7)<0.001
 Pleural thickening48 (65.8)19 (90.5)29 (55.8)0.0057.53 (1.59–35.73)14 (100)34 (57.6)0.003
 Nodule(s)62 (84.9)16 (76.2)46 (88.5)0.1850.42 (0.11–1.56)10 (71.4)52 (88.1)0.1160.337 (0.08–1.37)
 Bronchiectasis54 (74.0)16 (76.2)38 (73.1)0.7841.17 (0.36–3.82)12 (85.7)42 (71.2)0.2652.43 (0.49–12.02)
 Destroyed lung3 (4.1)3 (14.3)00.0213 (21.4)00.006

Data are presented as n (%), unless otherwise stated. CPA: chronic pulmonary aspergillosis; CT: computed tomography. #: these features formed part of the CPA case definition. All p-values calculated by Fisher's exact test. Odds ratios were calculated by bimodal regression analysis. p<0.05 considered significant.