Characteristic | Regimen | p-value | |
Regular (n=76) | Optimised (n=76) | ||
Age years | 0.165 | ||
Mean | 37.1±12.3 | 34.6±11.8 | |
Median | 36.5 (27–47) | 33.5 (25–41) | |
Sex | 0.116 | ||
Male | 57 (75.0) | 47 (61.8) | |
Female | 19 (25.0) | 29 (38.2) | |
BMI kg·m−2 | 0.320 | ||
Mean | 19.5±2.4 | 19.8±2.5 | |
Median | 19.4 (18.0–20.8) | 19.5 (18.4–21.2) | |
Occupation | 0.650 | ||
Farmer | 25 (32.9) | 26 (34.2) | |
Labourer | 16 (21.1) | 19 (25.0) | |
Employed | 10 (13.2) | 14 (18.4) | |
Unemployed | 15 (19.7) | 10 (13.2) | |
Other | 10 (13.2) | 7 (9.2) | |
TB symptoms | |||
Cough | 67 (88.2) | 62 (81.6) | 0.258 |
Expectoration | 58 (76.3) | 62 (81.6) | 0.426 |
Haemoptysis | 33 (43.4) | 51 (67.1) | 0.003 |
Fever | 17 (22.4) | 34 (44.7) | 0.006 |
Chest pain | 9 (11.8) | 8 (10.5) | 0.797 |
Dyspnoea | 7 (9.2) | 14 (18.4) | 0.157 |
Fatigue | 15 (19.7) | 23 (30.3) | 0.134 |
Chest radiograph | |||
Presence of cavity | 51 (67.1) | 58 (76.3) | 0.280 |
Bilateral involvement | 58 (75.0) | 61 (80.3) | 0.776 |
Medical history of diabetes mellitus | 19 (26.3) | 14 (18.4) | 0.325 |
Any smoking history | 6 (7.9) | 10 (16.2) | 0.429 |
Alcohol consumption | 5 (6.6) | 6 (7.9) | 0.763 |
Previous second-line drugs | 0.819 | ||
Never treated | 59 (77.6) | 62 (81.6) | |
Treatment-naïve | 16 (21.1) | 8 (10.5) | |
First-line only | 43 (56.6) | 54 (71.1) | |
One second-line drug | 13 (17.1) | 11 (14.5) | |
Fluoroquinolones | 9 (11.8) | 6 (7.9) | |
Aminoglycosides | 4 (5.3) | 5 (6.6) | |
Two or more second-line drugs | 4 (5.3) | 3 (3.9) |
Data is reported as n (%), mean±sd and median (IQR), unless otherwise stated. BMI: body mass index; TB: tuberculosis.