Baseline demographic and clinical characteristics of patients included in the validation cohort (PROMISE-COPD study)
| Subjects | 506 |
| Age years | 66.8±10.5 |
| Male | 366 (71.9) |
| Weight kg | 74.9±17.0 |
| Height cm | 169.0±8.0 |
| BMI kg·m−2 | 26.2±5.5 |
| COPD history | |
| Current smokers | 150 (29.6) |
| Pack-years | 51.5±30.9 |
| Duration of COPD symptoms months | 102.7±89.1 |
| Time elapsed since diagnosis months | 80.2±74.6 |
| Exacerbations in previous year n | 1 (0–1) |
| Severe exacerbations in previous year n | 0 (0–1) |
| Modified MRC dyspnoea grade | 1 (1–2) |
| 6MWD m | 380.3±104.2 |
| BODE index | 3 (1–4) |
| Borg score | 4 (3–6) |
| SaO2 at rest % | 94.5±2.7 |
| Lowest SaO2 at exercise % | 89.5±5.7 |
| Age-adjusted Charlson score | 4±1.8 |
| SGRQ score | |
| Symptoms | 49.0±22.7 |
| Activity | 57.4±22.8 |
| Impact | 32.2±18.7 |
| Total | 42.4±18.1 |
| SF-36 score | |
| Physical function | 51.4±25.9 |
| Role physical | 51.7±43.5 |
| Role emotional | 67.5±42.9 |
| Social functioning | 69.8±28.2 |
| Mental health | 65.4±19.8 |
| Body pain | 73.9±27.6 |
| Vitality | 51.9±20.9 |
| General health | 48.2±23.1 |
| GOLD grade# | |
| II | 254 (50.2) |
| III | 177 (34.9) |
| IV | 75 (14.8) |
| Lung function parameters | |
| Post-bronchodilation FVC % pred | 77.8±24.8 |
| Post-bronchodilation FEV1 % pred | 48.6±18.2 |
| Post-bronchodilation FEV1/FVC % pred | 48.2±14.1 |
| RV % pred | 157.4±45.6 |
| TLC % pred | 118.8±20.2 |
| RV/TLC % pred | 53.7±9.6 |
| DLCO % pred | 55.6±20.7 |
| Quantitative CT scan parameters (n=150) | |
| Low-attenuation area < −950 HU % | 13.8 (5.0–26.1) |
| Adjusted lung density g·L−1 | 53.5 (29.0–76.0) |
| Lung volume L | 5.4 (4.5–6.5) |
| Positive sputum bacteriology | 50/155 (32.2) |
Data are presented as n, mean±sd, n (%), median (interquartile range) or n/N (%). BMI: body mass index; COPD: chronic obstructive pulmonary disease; MRC: Medical Research Council; 6MWD: 6-min walk distance; BODE: body mass, airflow obstruction, dyspnoea, exercise capacity; SaO2: arterial oxygen saturation; SGRQ: St George's Respiratory Questionnaire; SF-36: Short Form-36; GOLD: Global Initiative for Chronic Obstructive Lung Disease; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; RV: residual volume; TLC: total lung capacity; DLCO: diffusing capacity of the lung for carbon monoxide; CT: computed tomography. #: GOLD grades are based on FEV1 % pred: II, ≥50% to <80%; III, ≥30% to <50%; IV, ≤30%.