Correlation analysis (Spearman's rho) of hyaluronic acid (HA) and hyaluronidase (HYAL)-1 in serum of chronic obstructive pulmonary disease patients at stable state (n=506) included in the validation cohort with biomarkers of extracellular matrix turnover
| HA | HYAL-1 | |||
| r | p-value | r | p-value | |
| Pro-collagen type III | 0.204 | <0.001 | 0.131 | 0.104 |
| Pro-collagen type V | −0.057 | 0.251 | 0.060 | 0.490 |
| Pro-collagen type VI | 0.182 | <0.001 | 0.270 | 0.001 |
| Collagen type I degradation products | −0.047 | 0.349 | 0.002 | 0.979 |
| Collagen type III degradation products | −0.001 | 0.979 | 0.120 | 0.136 |
| Collagen type IV degradation products (α1 chain) | −0.035 | 0.482 | 0.053 | 0.550 |
| Collagen type IV degradation products (α3 chain) | −0.063 | 0.206 | 0.203 | 0.020 |
| Collagen type VI degradation products | −0.015 | 0.738 | 0.201 | 0.012 |
| Neutrophil elastase-generated fragments of elastin | −0.004 | 0.932 | 0.114 | 0.158 |