TABLE 1

Multivariate analysis using complete home treatment and early discharge as the dependent variable#

Variables (number of patients)Home versus in hospital therapy OR (CI)Early discharge (≤5 days) or home treatment versus admission >5 days OR (CI)
Clinical characteristics
 Age >65 years0.59 (0.46–0.76)***0.77 (0.69–0.86)***
 Male sex (n=5413)1.19 (1.08–1.32)***
 Body weight <75 kg1.12 (1.02–1.24)*
Initial presentation
 Pulse >110 beats per min (n=2214)0.33 (0.23–0.48)***0.62 (0.55–0.71)***
 Systolic BP levels <100 mmHg (n=888)0.50 (0.26–0.93)*
 Temperature <36°C (n=756)0.82 (0.68–0.99)*
Risk factors
 Cancer (n=2550)2.55 (2.00–3.27)***1.30 (1.16–1.45)***
 Immobility ≥4 days (n=1663)0.82 (0.71–0.95)**
 Oestrogen therapy (n=630)1.68 (1.37–2.07)***
Underlying conditions
 Chronic heart failure (n=931)0.74 (0.61–0.89)**
 Chronic lung disease (n=1598)0.80 (0.70–0.92)**
 Creatinine clearance levels <60 mL·min−1 (n=3963)0.81 (0.72–0.91)***
Countries
 Spain (n=8270)Ref.***Ref.***
 Italy (n=593)5.17 (3.11–8.58)***
 France (n=964)0.48 (0.25–0.90)*
 Israel (n=429)0.36 (0.13–0.97)*2.12 (1.68–2.67)***
 Other countries (n=1217)11.50 (9.02–14.66)***2.25 (1.93–2.62)***
Initial therapy
 LMWH (n=9935)Ref.***Ref.***
 Unfractionated heparin (n=647)0.16 (0.07–0.35)***0.36 (0.28–0.46)***
 Thrombolytics (n=328)0.35 (0.24–0.50)***
 DOACs (n=196)5.26 (3.36–8.24)***2.92 (2.08–4.09)***
 Fondaparinux (n=297)0.41 (0.25–0.67)***
Type of hospital
 University hospital (n=7025)2.29 (1.74–3.01)***1.11 (1.01–1.23)*
Scores
 PESI <85 points (n=4792)1.20 (0.98–1.47)1.33 (1.21–1.46)***
 RIETE <1 point (n=3347)1.29 (1.04–1.60)*1.57 (1.42–1.74)***
 ACCP scheme ≤1 point (n=1759)1.29 (0.98–1.69)1.46 (1.28–1.66)***

BP: blood pressure; LMWH: low-molecular-weight heparin; Ref.: reference; DOACs: direct oral anticoagulants; PESI: Pulmonary Embolism Severity Index; ACCP: American College of Chest Physicians. #: patients dying ≤24 h after the index event were excluded from this analysis; : modified version (information on control of anticoagulation was unavailable in the RIETE registry). Scores included one by one excluding all the variables already counted in each score. *: p<0.05; **: p<0.01; ***: p<0.001.