Definitions of acute and long-term response

Acute pulmonary vasoreactivity# for patients with idiopathic, hereditable or drug-induced PAHReduction of mPAP ≥10 mmHg to reach an absolute value of mPAP ≤40 mmHg
Increased or unchanged cardiac output
Long-term response to CCBsNew York Heart Association Functional Class I/II
With sustained haemodynamic improvement (same or better than achieved in the acute test) after at least 1 year on CCBs only

PAH: pulmonary arterial hypertension; mPAP: mean pulmonary arterial pressure; CCB: calcium channel blocker. #: nitric oxide (10–20 ppm) is recommended for performing vasoreactivity testing, but i.v. epoprostenol, i.v. adenosine or inhaled iloprost can be used as alternatives.