TABLE 3

Contingency tables for biomarker cut-off points with T2-high and T2-low asthma defined by the in vitro stimulation of airway epithelial lung cells with interleukin (IL)-13 (IL-13 IVS) signature

T2-highT2-lowp-value
FeNO ≥30 ppb23190.001
FeNO <30 ppb1244
Blood eosinophils ≥300cells·µL−119180.026
Blood eosinophils <300 cells·µL−11848
Serum periostin ≥55 µg·L−19120.59
Serum periostin <55 µg·L−12346
Blood eosinophils ≥300 µg·L−1 and FeNO ≥30 ppb1360.002
Blood eosinophils <300 µg·L−1 and FeNO <30 ppb2257
Blood eosinophils ≥300 µg·L−1 and serum periostin ≥55 µg·L−1760.24
Blood eosinophils <300 µg·L−1 and serum periostin <55 µg·L−12857
FeNO ≥30 ppb and serum periostin ≥55 µg·L−1740.24
FeNO <30 ppb and serum periostin <55 µg·L−12859
Blood eosinophils ≥300 µg·L−1 and FeNO ≥30 ppb and serum periostin ≥55 µg·L−1620.02
Blood eosinophils <300 µg·L−1 and FeNO <30 ppb and serum periostin <55 µg·L−12961

Data are presented as n, unless otherwise stated. FeNO: exhaled nitric oxide fraction.