Contingency tables for biomarker cut-off points with T2-high and T2-low asthma defined by the in vitro stimulation of airway epithelial lung cells with interleukin (IL)-13 (IL-13 IVS) signature
T2-high | T2-low | p-value | |
FeNO ≥30 ppb | 23 | 19 | 0.001 |
FeNO <30 ppb | 12 | 44 | |
Blood eosinophils ≥300 cells·µL−1 | 19 | 18 | 0.026 |
Blood eosinophils <300 cells·µL−1 | 18 | 48 | |
Serum periostin ≥55 µg·L−1 | 9 | 12 | 0.59 |
Serum periostin <55 µg·L−1 | 23 | 46 | |
Blood eosinophils ≥300 µg·L−1 and FeNO ≥30 ppb | 13 | 6 | 0.002 |
Blood eosinophils <300 µg·L−1 and FeNO <30 ppb | 22 | 57 | |
Blood eosinophils ≥300 µg·L−1 and serum periostin ≥55 µg·L−1 | 7 | 6 | 0.24 |
Blood eosinophils <300 µg·L−1 and serum periostin <55 µg·L−1 | 28 | 57 | |
FeNO ≥30 ppb and serum periostin ≥55 µg·L−1 | 7 | 4 | 0.24 |
FeNO <30 ppb and serum periostin <55 µg·L−1 | 28 | 59 | |
Blood eosinophils ≥300 µg·L−1 and FeNO ≥30 ppb and serum periostin ≥55 µg·L−1 | 6 | 2 | 0.02 |
Blood eosinophils <300 µg·L−1 and FeNO <30 ppb and serum periostin <55 µg·L−1 | 29 | 61 |
Data are presented as n, unless otherwise stated. FeNO: exhaled nitric oxide fraction.