TABLE 3

Contingency tables for biomarker cut-off points with T2-high and T2-low asthma defined by the in vitro stimulation of airway epithelial lung cells with interleukin (IL)-13 (IL-13 IVS) signature

	T2-high	T2-low	p-value
F_eNO ≥30 ppb	23	19	0.001
F_eNO <30 ppb	12	44	0.001
Blood eosinophils ≥300 cells·µL⁻¹	19	18	0.026
Blood eosinophils <300 cells·µL⁻¹	18	48	0.026
Serum periostin ≥55 µg·L⁻¹	9	12	0.59
Serum periostin <55 µg·L⁻¹	23	46	0.59
Blood eosinophils ≥300 µg·L⁻¹ and F_eNO ≥30 ppb	13	6	0.002
Blood eosinophils <300 µg·L⁻¹ and F_eNO <30 ppb	22	57	0.002
Blood eosinophils ≥300 µg·L⁻¹ and serum periostin ≥55 µg·L⁻¹	7	6	0.24
Blood eosinophils <300 µg·L⁻¹ and serum periostin <55 µg·L⁻¹	28	57	0.24
F_eNO ≥30 ppb and serum periostin ≥55 µg·L⁻¹	7	4	0.24
F_eNO <30 ppb and serum periostin <55 µg·L⁻¹	28	59	0.24
Blood eosinophils ≥300 µg·L⁻¹ and F_eNO ≥30 ppb and serum periostin ≥55 µg·L⁻¹	6	2	0.02
Blood eosinophils <300 µg·L⁻¹ and F_eNO <30 ppb and serum periostin <55 µg·L⁻¹	29	61	0.02

Data are presented as n, unless otherwise stated. F_eNO: exhaled nitric oxide fraction.