TABLE 3

Relationship of vitamin D binding protein (VTDB) genotype with clinical features, serum VTDB and change in lung function in the National Heart, Lung and Blood Institute Lymphangioleiomyomatosis (LAM) Registry cohort

	rs4588 SNP				rs7041 SNP
	AA	CA	CC	p-value	TT	GT	GG	p-value
Subjects n	11	46	74		25	57	48
Age at diagnosis years	37.4±6.7	42.1±9.9	40.6±9.2	ns	39.9±7.6	41.8±9.7	40.5±9.6	ns
Age at recruitment years	40.9±6.4	47.2±9.4	45.3±8.9		43.8±7.5	46.4±9.4	45.4±9.3
FEV₁ % pred	88.0±21.0	78.8±25.2	72.9±29.4	ns	79.9±26.8	79.0±30.2	72.0±24.0	ns
D_LCO % pred	58.3±17.5	59.5±22.5	57.0±29.3	ns	56.3±18.2	58.1±30.8	58.9±23.2	ns
VTDB µg·mL⁻¹	220±36	245±57	266±52	0.022	233±43	250±57	270±53	0.026
ΔFEV₁ mL per year	−125±142	−78±81	−99±97	ns	−135±126	−80±84	−94±94	ns
ΔD_LCO mmol·min⁻¹·kPa⁻¹ per year	−0.35±0.23	−0.21±0.36	−0.22±0.3	ns	−0.26±0.27	−0.20±0.35	−0.26±0.27	ns

Data are presented as mean±sd for women with LAM of European ancestry, unless otherwise stated (data for forced expiratory volume in 1 s (FEV₁) % pred, diffusing capacity of the lung for carbon monoxide (D_LCO) % pred, VTDB and age at recruitment were all at entry to the study; ΔFEV₁ and ΔD_LCO are prospective changes from recruitment). Linear regression was used to model the relationship between genotype, clinical factors and VTDB. ns: nonsignificant.