TABLE 4

Projected costs of strategies using digital support for active tuberculosis (TB) treatment, in 2016 USD

Digital support strategyCost per personIncremental savings versus DOT
Drug-susceptible TB cohort
 Health system perspective
  DOT930 (876–1095)Comparator
  VOT567 (529–660)363 (302–490)
  MM: Wisepill423 (392–511)507 (450–631)
  MM: 99DOTS394 (363–482)536 (479–660)
 Societal perspective
  DOT1249 (903–3069)Comparator
  VOT718 (572–1170)531 (69–2320)
  MM: Wisepill574 (431–1032)675 (217–2394)
  MM: 99DOTS545 (402–1003)704 (249–2463)
MDR-TB cohort
 Health system perspective
  DOT12 585 (12 395–13 184)Comparator
  VOT11 177 (11 027–11 563)1409 (1212–1826)
  MM: Wisepill10 754 (10 623–11 128)1831 (1648–2235)
  MM: 99DOTS10 715 (10 584–11 089)1870 (1686–2274)
 Societal perspective
  DOT13 650 (12 537–19 923)Comparator
  VOT11 648 (11 224–12 769)2002 (371–8095)
  MM: Wisepill11 225 (10 817–12 358)2425 (789–8195)
  MM: 99DOTS11 186 (10 779–12 319)2463 (828–8234)

Data are presented as cost or savings with 95% uncertainty ranges. DOT: directly observed treatment; VOT: video-observed therapy; MM: medication monitor; MDR: multidrug-resistant.