TABLE 1

Baseline demographic and clinical information of all patients recruited

All patientsNTM statusp-value
+
Subjects1064561
Age years67.5±10.767.6±10.167.3±11.30.88
Female95 (89)37 (82)58 (95)0.71
Caucasian92 (87)34 (76)58 (95)0.39
BMI kg·m−222.7±4.324.2±5.221.5±3.1<0.01
Smoking packs per day1.3±2.21.2±1.01.4±3.00.85
Smoking years19.2±13.122.9±14.515.1±9.90.04
Symptoms
 Cough63 (59)22 (49)41 (67)0.07
 Sputum47 (44)14 (31)33 (54)0.15
 Haemoptysis8 (8)3 (7)5 (8)0.76
 Shortness of breath42 (39)17 (38)25 (41)0.92
 Wheeze14 (13)7 (16)7 (11)0.6
 Fatigue26 (25)9 (20)17 (28)0.6
 Post-nasal drip36 (34)19 (42)17 (28)0.03
 Sinusitis4 (4)4 (9)0 (0)0.03
Current NTM culture
 MAC56 (53)0 (0)56 (92)<0.001
M. abscessus5 (5)0 (0)5 (8)<0.05
Current bacterial culture
 Oropharyngeal flora15 (14)4 (9.5)11 (18)0.13
 P. aeruginosa6 (6)1 (2)5 (8)0.19
 MSSA5 (5)2 (4)3 (5)0.91
 Other10 (9)4 (9.5)6 (10)0.89
 Negative culture17 (16)9 (20)8 (13)0.34
Lung physiology#
 FVC % pred92.7±20.192.6±20.492.8±20.00.97
 FEV1 % pred83.7±21.883.4±22.184.0±21.80.91
 FEV1/FVC %70.2±10.669.2±10.771.0±10.60.44
 RV % pred121.8±31.7118.4±32.8124.5±31.00.41
 TLC % pred106.4±18.5105.6±16.2106.9±20.20.76
DLCO % pred87.4±20.790.7±23.785.4±18.70.35
HRCT thorax
 Bronchiectasis79 (75)34 (76)45 (78)0.45
 Thickened airways52 (49)23 (51)29 (59)0.73
 Mucoid impaction54 (51)20 (44)34 (74)0.57
 Nodules70 (66)29 (64)41 (67)0.29
 Tree-in-bud30 (28)11 (24)19 (31)0.41
 Ground-glass opacification31 (29)17 (38)14 (23)0.16
Questionnaire data
 SGRQ total score27.5±19.328.4±21.126.8±18.10.68
 RSI total11.9±9.213.7±9.410.7±8.90.12
 FSSG total8.5±8.59.8±9.77.6±7.50.22
 EAT-10 total3.0±5.83.0±5.640.8±20.00.97

Data are presented as n, mean±sd or n (%), unless otherwise stated. NTM: nontuberculous mycobacteria; BMI: body mass index; MAC: Mycobacterium avium complex; M. abcessus: Mycobacterium abscessus; P. aeruginosa: Pseudomonas aeruginosa; MSSA: methicillin-sensitive Staphylococcus aureus; FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s; RV: residual volume; TLC: total lung capacity; DLCO: diffusion capacity of the lung for carbon monoxide; HRCT: high-resolution computed tomography; SGRQ: St George's respiratory questionnaire; RSI: reflux symptom index; FSSG: frequency scale for the symptoms of gastro-oesophageal reflux disease; EAT-10: eating assessment tool. #: n=89; : n=101.