TABLE 2

Cell count, and in vivo cytokine levels in bronchoalveolar lavage of 20 patients from the bronchoscopy cohort

NTMp-value#NTM+p-value#
InvolvedNon-involvedInvolvedNon-involved
Subjects n128
Cell count
 Macrophages44.2 (28.2–75.7)75.4 (51.7–80.4)ns19.6 (15.75–39.65)75.4 (66.0–85.0)0.02+
 Neutrophils52.8 (13.4–69.8)13.2 (10.5–35.05)ns79.6 (58.2–82.75)17.1 (6.5–31.2)0.02+
 Lymphocytes2.8 (2.6–10.9)11.4 (2.95–12.7)0.022.2 (1.7–2.45)1.8 (0.5–3.8)ns
 Eosinophils0 (0–0)0 (0–0)ns0 (0–0)0 (0–0)ns
In vivo cytokine level pg·mL−1
 ITAC19.39 (19.4–224.4)224.4 (135.6–274.9)ns426.4 (372.5–1135.8)469.73 (352.8–489.7)0.02§
 MIP1β64.875 (60.7–114.2)83.545 (61.8–109.2)ns138.08 (134.1–188.8)111.83 (71.8–141.4)0.02§
 IFN-γ21.36 (6.4–30)8.46 (6.7–13.8)ns63.085 (24.8–158.6)22.095 (17.6–26.5)0.03§
 IL-8423.565 (216.9–486.8)351.12 (240.7–1810.2)ns5927.82 (5927.8–5927.8)411.345 (242.8–586.8)0.03§
 IL-12 p703.95 (3.7–4.1)3.715 (3.5–4.3)ns5.155 (4.2–6.6)4.605 (4.3–4.6)0.06
 MIP1α116.88 (66.2–179.7)95.855 (72.4–128.3)ns268.83 (143.4–489.8)117.975 (78.5–143.1)0.06
 MIP3α49.105 (51.9–86.3)86.26 (75.6–254.4)0.03356.01 (300.8–443.1)201.49 (141.7–228.2)ns
 IL-17A9.65 (10.1–18.2)18.18 (15–20.7)0.0611.02 (10.5–13.2)15.44 (10.4–19.9)ns
 IL-137.445 (8.3–19.3)13.97 (11.3–17.9)ns9.73 (8.6–12)70.87 (9.4–145.9)ns
 IL-22.75 (2.8–4.7)4.68 (3.6–5.5)ns5.07 (3.7–8.3)2.80 (2.8–4.3)ns
 Fractalkine364.12 (364.1–391.3)391.255 (360.4–449.6)ns488.115 (455.5–544.1)558.94 (403.9–558.9)ns
 IL-1β22.27 (1.9–11.1)3.94 (2–6.5)ns34.345 (3.8–72.4)2.405 (2.1–65.3)ns
 IL-611.275 (10.1–104)104.025 (58.9–154.3)ns82.735 (60.9–133.4)114.99 (69.7–147.3)ns
 IL-214.825 (4.5–6.5)5.95 (4.7–7.3)ns6.655 (6–8.8)7.45 (5.4–9.17)ns
 IL-715.935 (15.2–38.4)24.97 (16.1–36.4)ns27.365 (26.7–31.6)29.545 (22.8–33.6)ns
 IL-532.475 (13.4–40.3)17.03 (12.1–23.2)ns26.395 (23.9–31.4)56.18 (56.2–18.4)ns
 IL-23158.025 (88.4–160.6)118.66 (88.4–149.9)ns153.865 (126.4–173.7)252.9 (165.4–359.9)ns
 TNF-α208.485 (36.1–231.5)44.63 (37.5–105.5)ns90.83 (67.3–130.3)54.845 (39.4–105.2)ns
 GM-CSF19.225 (18.1–41.2)29.935 (19.6–40)ns35.795 (32.1–42.2)27.215 (22.5–37.0)ns
 IL-429.09 (22–30.5)25.42 (22.9–32.6)ns39.855 (31–50.2)46.31 (37.1–49.0)ns
 IL-1061.015 (50.8–84.6)66.315 (55.1–74)ns45.74 (32.1–68.6)83.5 (68.2–89.1)ns

Data are presented as median (interquartile range), unless otherwise stated. NTM: nontuberculous mycobacteria; ITAC: interferon (IFN)-γ-inducible T-cell α chemoattractant; MIP: macrophage inflammatory protein; IL: interleukin; TNF: tumour necrosis factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; ns: nonsignificant; FDR: false discovery rate. #: Mann–Whitney U-test; : comparing involved sites by NTM status; +: FDR <0.05; §: FDR <0.2.