Heritability of diffusing capacity of the lung
| Rotterdam Study | Framingham Heart Study | |||||||
| DLCO | DLCO/VA | DLCO | DLCO/VA | |||||
| h2±se | p-value | h2±se | p-value | h2±se | p-value | h2±se | p-value | |
| Subjects n | 3286+ | 6246§ | ||||||
| Model 1# | 0.23±0.10 | 0.01 | 0.24±0.10 | 0.009 | 0.49±0.03 | 2.3×10–106 | 0.45±±0.03 | 5.0×10–82 |
| Model 2¶ | 0.28±0.10 | 0.002 | 0.25±0.10 | 0.0075 | 0.47±0.03 | 8.5×10–100 | 0.46±0.03 | 7.6×10–84 |
DLCO: diffusing capacity of the lung for carbon monoxide; VA: alveolar volume; h2: heritability estimate. #: adjusted for age, sex and principal components of genetic relatedness (Rotterdam Study only); ¶: adjusted for age, sex, smoking and principal components of genetic relatedness (Rotterdam Study only); +: unrelated individuals; §: individuals with known family relationships.