Clinical parameter | FIS | SCC | ||||
Low | High | p-value | High | Low | p-value | |
Patients n | 25 | 9 | 26 | 8 | ||
Length z-score | ||||||
Mean±sd | 0.15±0.8 | 0.14±1.29 | 1.00 | 0.07±0.80 | 0.39±1.32 | 0.54 |
Missing | 0 | 0 | 0 | 0 | ||
Weight for length z-score | ||||||
Mean±sd | −0.14±0.79 | −0.50±0.79 | 0.25 | 0.19±0.81 | −0.38±0.79 | 0.58 |
Missing | 0 | 0 | 0 | 0 | ||
IRT µg·mL−1 | ||||||
Median (IQR) | 160 (137–208) | 123 (86–142) | 0.030 | 160 (140–207) | 109 (84–138) | 0.012 |
Missing | 0 | 0 | 0 | 0 | ||
PAP µg·mL−1 | ||||||
Median (IQR) | 5.9 (4.5–10.0) | 3.0 (1.8–5.2) | 0.039 | 5.9 (3.7–9.9) | 3.9 (2.0–4.8) | 0.053 |
Missing | 1 | 0 | 1 | 0 | ||
Pancreatic sufficiency n (%) | ||||||
Sufficient (FE >200 µg·g−1) | 2 (8) | 7 (78) | <0.001 | 2 (8) | 7 (88) | <0.001 |
Partially insufficient (FE 15–200 µg·g−1) | 4 (16) | 0 (0) | 4 (15) | 0 (0) | ||
Insufficient (FE<15 µg·g−1) | 19 (76) | 2 (22) | 20 (77) | 1 (12) | ||
Missing | 0 | 0 | 0 | 0 | ||
Leeds score¶ | ||||||
Median (IQR) | 6.0 (4.0–12.0) | 4.0 (3.0–8.0) | 0.26 | 6.0 (4.0–12.0) | 3.5 (2.0–5.0) | 0.051 |
Missing | 0 | 0 | 0 | 0 | ||
BALF % neutrophils | ||||||
Median (IQR) | 10.0 (4.0–23.8) | 10.0 (9.0–13.0) | 0.82 | 10.0 (4.0–20.5) | 10.0 (9.0–22.0) | 0.96 |
Missing | 11 | 4 | 12 | 3 | ||
PRAGMA-CF CT score % disease | ||||||
Median (IQR) | 3.6 (2.4–4.9) | 1.8 (0.8–2.3) | 0.049 | 3.7 (2.4–4.8) | 1.3 (0.6–2.0) | 0.007 |
Missing | 1 | 2 | 1 | 2 | ||
V′max-FRC z-score | ||||||
Median (IQR) | −1.9 (−2.5– −0.9) | −0.2 (−1.0– −0.1) | 0.033 | −1.0 (−2.4– −0.5) | −1.0 (−1.6– −0.3) | 0.46 |
Missing | 15 | 2 | 15 | 2 |
IRT: immunoreactive trypsinogen; IQR: interquartile range; PAP: pancreatitis-associated protein; FE: faecal elastase; BALF: bronchoalveolar lavage fluid; PRAGMA-CF: Perth–Rotterdam Annotated Grid Morphometric Analysis for CF; CT: computed tomography; V′max-FRC: maximal expiratory flow at functional residual capacity. #: see text and figure 3 for borders between high and low values for FIS and SCC; ¶: accumulated colonisation status of different cystic fibrosis pathogens (Pseudomonas aeruginosa, Staphylococcus aureus, Haemophilus influenzae). Bold indicates significance at p<0.05.