TABLE 1

Baseline characteristics of patients with chronic thromboembolic pulmonary hypertension (CTEPH)

CTEPH (whole cohort)CTEPH-operated groupCTEPH-technically-operable- not-operated groupCTEPH-nonsurgical-disease- distribution group
Subjects550 (100)272 (49)176 (32)102 (19)
Age years63±1558±14,+69±14#65±15#
Female5045+,50#62#
BMI kg·m−229±730±729±829±6
Duration of symptoms
 <1 year15141712
 1–2 years38403533
 2–5 years24271928
 >5 years16161418
 Not clear83149
WHO FC I/II versus III/IV11/8913/87+11/893/97#
ISWD m189±177232±185,+142±157#155±160#
RAP mmHg11±511±511±612±5
mPAP mmHg46±1147±1143±11#,+48±12
Cardiac index L·min−1·m−22.5±0.82.5±0.72.6±0.82.5±0.8
PCWP mmHg12±512±412±611±4
PVR WU7.7±4.37.7±47±4.6+8.7±4.5
SvO2 %61±861±861±961±9
FEV1 % pred80±3583±4375±23#80±24
FVC % pred92±2495±2189±2590±27
DLCO % pred61±1765±1555±19#,+61±17
History of acute VTE7174+74+57#,
IVC filter3351
Thrombophilia5633
History of cancer116,+15#15#
Smoking38384330
Obesity36393232
Splenectomy53+3+12#,
Thyroid disorder128+1418#
VA shunt/PPM infection2204
IBD1122
CAD1110147
LV dysfunction428#,+2
Valvular heart disease2222
CKD7313#6
COPD191330#19
PH therapy following diagnosis7674+72+86#,

Data are presented as n (%), mean±sd or %. BMI: body mass index; WHO FC: World Health Organization Functional Class; ISWD: incremental shuttle walk distance; RAP: right atrial pressure; mPAP: mean pulmonary arterial pressure; PCWP: pulmonary capillary wedge pressure; PVR: pulmonary vascular resistance; WU: Wood units; SvO2: mixed venous oxygen saturation; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide; VTE: venous thromboembolism; IVC: inferior vena cava; VA: ventriculo-atrial; PPM: permanent pacemaker; IBD: inflammatory bowel disease; CAD: coronary artery disease; LV: left ventricular; CKD: chronic kidney disease; COPD: chronic obstructive pulmonary disease; PH: pulmonary hypertension. #: p<0.05 compared with CTEPH-operated; : p<0.05 compared with CTEPH-technically-operable-not operated; +: p<0.05 compared with CTEPH-nonsurgical-disease-distribution.