Modulated metabolite pathways in mice and humans during fibrosis and upon pirfenidone treatment
| Discriminative pathways | Bleomycin-induced pulmonary fibrosis | Idiopathic pulmonary fibrosis |
| Reduced in fibrosis | ||
| Glycolysis/gluconeogenesis | Yes | No |
| Linoleic acid metabolism | No | Yes |
| Inositol phosphate metabolism | No | Yes |
| Starch and sucrose metabolism | No | Yes |
| Enhanced in fibrosis | ||
| Pentose and glucuronate interconversions | Yes | Yes |
| Ascorbate and aldarate metabolism | Yes | Yes |
| Amino sugar and nucleotide sugar metabolism | Yes | No |
| Pentose phosphate pathway | Yes | No |
| Fructose and mannose metabolism | Yes | Yes |
| Vitamin B6 metabolism | No | Yes |
| Glutathione metabolism | No | Yes |
| Reduced upon pirfenidone | ||
| Ascorbate and aldarate metabolism | Yes | No |
| Enhanced upon pirfenidone | ||
| Glycolysis/gluconeogenesis | No | Yes |