Frequency of comorbidities in individuals with α1-antitrypsin deficiency (AATD) and in the reference group of chronic obstructive pulmonary disease without AATD
| AATD patients | Non-AATD patients | p-value | |
| Subjects | 157 | 506 | |
| Asthma | 59 (37.6) | 227 (44.9) | 0.13 |
| Bronchiectasis | 7 (4.5) | 18 (3.6) | 0.78 |
| Rhinitis | 2 (1.3) | 5 (1.0) | 0.67 |
| Gastro-oesophageal reflux disease | 2 (1.3) | 7 (1.4) | 1.00 |
| Eczema | 2 (1.3) | 14 (2.8) | 0.38 |
| Osteoporosis | 8 (5.1) | 28 (5.5) | 0.99 |
| Chronic kidney disease | 0 (0.0) | 7 (1.4) | 0.21 |
| Diabetes | 12 (7.6) | 66 (13.0) | 0.09 |
| Hypertension | 8 (5.1) | 43 (8.5) | 0.22 |
| Cardiovascular disease | 15 (9.6) | 70 (13.8) | 0.21 |
| Ischaemic heart disease | 9 (5.7) | 27 (5.3) | 1.00 |
| Heart failure | 2 (1.3) | 4 (0.8) | 0.63 |
| Myocardial infarction | 2 (1.3) | 9 (1.8) | 1.00 |
| Cerebrovascular disease | 1 (0.6) | 14 (2.8) | 0.21 |
| Anxiety and/or depression | 11 (7.0) | 50 (9.9) | 0.35 |
Data are presented as n or n (%), unless otherwise stated. p-values from Fisher's exact test or the Chi-squared test, as appropriate.