TABLE 3

Historical milestones in the understanding and management of idiopathic pulmonary fibrosis (IPF)

Year	Event	Reference
1935	Description of “fulminating diffuse interstitial fibrosis of the lungs” by L. Hamman and A.R. Rich	[89]
1968	First classification of interstitial pneumonias, A.A. Liebow and D. E. Smith, including usual or classical interstitial pneumonia (UIP)	[90]
1978	Individualisation of idiopathic pulmonary fibrosis (IPF) (or cryptogenic fibrosing alveolitis)	[91]
1981–1985	Individualisation of organising pneumonia	[94]
1984	IPF, an inflammatory disease of alveolar macrophage	[95]
1989–1991	Giant cell interstitial pneumonia (GIP) is related to exposure to hard metals and is not idiopathic	[96, 97]
1994	Description of non-specific interstitial pneumonia (NSIP)	[98]
2000	International consensus on IPF, defined by a UIP pattern at HRCT and/or biopsy, in idiopathic setting	[99]
2001	IPF, a disease related to epithelial cell dysfunction and myofibroblast dysfunction	[8]
2002	International ATS/ERS/JRS/ALAT classification of idiopathic interstitial pneumonias (IIPs), including NSIP	[1]
2002	Description of acute fibrinous organising pneumonia (AFOP)	[100]
2005	Individualisation of combined pulmonary fibrosis and emphysema syndrome (CPFE)	[101]
2007	Description of familial pulmonary fibrosis associated with telomerase complex mutations	[102]
2011	International ATS/ERS/JRS/ALAT guidelines on diagnosis and management of IPF	[3]
2011	IPF is associated with a common polymorphism in the promoter of MUC5B	[7]
2013	Update of international ATS/ERS/JRS/ALAT classification of IIPs, including pleuroparenchymal fibroelastosis, AFOP, unclassifiable IIPs and a disease behaviour classification	[19]
2014	Demonstration of efficacy of pirfenidone and nintedanib in IPF	[38, 103]
2015	Update of ATS/ERS/JRS/ALAT treatment guidelines on IPF	[104]
2017	Expert group endorsement of multidisciplinary diagnosis of IPF in patients not meeting formal guideline diagnostic criteria	[105]