TABLE 7

Genetic models are affected by background; phenotypic presentation of transforming growth factor-β1 knockout in mice with different strains

StrainsPhenotypes
129/Sv x CF-150% mutants died embryonically, the rest survived postnatally, with massive inflammation primarily in heart and lung by 3–4 weeks of age [S121]
C57BL/6All mutants died during preimplantation [S122]
129/Sv x C57BL/6 x NIH/Olac50% mutants died of preimplantation, the rest died of a yolk sac developmental defect [S123]

For references listed in the table please refer to the supplementary material.