TABLE 8

Some cell type-specific Cre mouse lines used in lung research

Mouse line [Ref.]Targeted cells in lung tissueLung specificity
Shh-Cre# [S124]Ventral foregut endoderm-derived lung epithelial cellsNo
Nkx2–1-Cre [S125]Lung endoderm-derived epithelial cellsNo
Sftpc-CreERT2# [S126]Fetal airway epithelial cells and postnatal type II alveolar epithelial cellsYes
SFTPC-Cre [S127]Fetal lung epithelial cellsYes
SFTPC-rtTA/TetO-Cre [S128]Fetal airway epithelial cells and postnatal type II alveolar epithelial cellsYes
Aqp5-Cre#Type I alveolar epithelial cellsNo
Hopx-CreERT2# [S129, S130]Type I alveolar epithelial cellsNo
Scgb1a1-Cre [S131]Club cellsYes
Scgb1a1-rtTA/TetO-Cre [S132]Club cells and some type II alveolar epithelial cellsYes
Scgb1a1-CreER# [S133]Club cells and some type II alveolar epithelial cellsYes
FOXJ1-Cre [S134]Ciliated epithelial cellsNo
FOXJ1-CreERT2 [S135]Ciliated epithelial cellsNo
KRT5-CreERT2 [S136]Basal cellsNo
Dermo1-Cre# [S137, S138]Mesoderm-derived lung mesenchymal cellsNo
Tagln-Cre [S139]Smooth muscle cells (pulmonary vasculature)No
Acta2-Cre [S140]Smooth muscle cellsNo
Myh11-CreERT2 [S141]Smooth muscle cellsNo
Tbx4-rtTA/TetO-Cre [S142]Lung mesenchymal cellsYes
Tbx4-CreERT [S143]Lung mesenchymal cellsYes
Pdgfrb-Cre [S144, S145]Perivascular progenitor and smooth muscle cells, and pericytesNo
Cspg4-Cre [S146]Vascular smooth muscle cells and pericytesNo
Wt1-Cre [S147]Mesothelial cellsNo
Tek-Cre [S148]Endothelial cellsNo
Lyve1-Cre# [S149]Lymphatic endothelial cellsNo
Prox1-CreERT2 [S150]Lymphatic endothelial cellsNo
Wnt1-Cre [S151]Lung intrinsic neuronsNo
Ascl1-CreERT2# [S152, S153]Pulmonary neuronal endocrinal cells and some airway and alveolar epithelial cellsNo

#: knock-in mice; : transgene in Y chromosome. For references listed in the table please refer to the supplementary material.