Unadjusted and adjusted odds ratios (ORs) for overall mortality in patients with acute symptomatic pulmonary embolism (PE)
| Risk factor | OR (95% CI) | p-value | ||
| Unadjusted | Adjusted | Unadjusted | Adjusted | |
| Age (per year) | 1.02 (1.01–1.04) | – | <0.001 | – |
| Male gender | 0.86 (0.61–1.21) | – | 0.38 | – |
| Non-adherent management | 2.94 (2.05–4.20) | 2.39 (1.57–3.61) | <0.001 | <0.001 |
| Anticoagulant use | 2.96 (1.87–4.68) | 2.63 (1.65–4.21) | <0.001 | <0.001 |
| Thrombolytic use | 2.29 (1.40–3.75) | 1.45 (0.77–2.72) | <0.01 | 0.25 |
| Filter use | 3.26 (2.14–4.97) | 3.14 (1.93–5.11) | <0.001 | <0.001 |
| COPD | 1.64 (0.96–2.80) | – | 0.07 | – |
| Congestive heart failure | 2.39 (1.37–4.18) | – | <0.01 | – |
| Recent major bleeding# | 3.06 (1.60–5.84) | 1.66 (0.83–3.35) | <0.01 | 0.15 |
| Presence of DVT | 1.78 (1.19–2.69) | – | <0.01 | – |
| SBP <90 mmHg | 3.79 (2.09–6.87) | 2.12 (1.11–4.05) | <0.001 | 0.02 |
| HR ≥110 bpm | 1.51 (1.02–2.22) | – | 0.04 | – |
| Arterial oxyhaemoglobin saturation <90% | 1.97 (1.38–2.80) | – | <0.001 | – |
| Dyspnoea | 1.83 (1.17–2.85) | – | <0.01 | – |
| Chest pain | 0.51 (0.35–0.74) | – | <0.001 | – |
| Syncope | 0.49 (0.26–0.92) | – | 0.03 | – |
| Cancer¶ | 3.63 (2.56–5.16) | – | <0.001 | – |
| Immobilization+ | 1.51 (1.10–2.06) | – | 0.01 | – |
The total number of subjects evaluated was 2096, with 140 deaths (the final model Chi-squared result was 38.78; p<0.001). COPD: chronic obstructive pulmonary disease; DVT: deep vein thrombosis; SBP: systolic blood pressure; HR: heart rate. #: in the previous month. ¶: active or under treatment in the last year. +: immobilised patients are defined in this analysis as non-surgical patients who were immobilised (i.e. total bed rest with bathroom privileges) for ≥4 days in the month prior to PE diagnosis.