Cut-off | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | CC % | LR+ % (95% CI) | LR− % (95% CI) | False positive (treated unnecessarily) |
Combined GeneXpert and ELISPOT >4000 BAL lymphocytes | 99 (96–100) | 98 (94–100) | 98 (94–100) | 99 (96–100) | 98.2 | 42 (10.7–165.2) | 0.01 (0–0.1) | 2/166 (1.2%) |
Test performance of this stepwise approach of combined GeneXpert and ELISPOT refers to 166 individuals (100 BAL and 66 sputum). PPV: positive predictive value; NPV: negative predictive value; CC: correctly classified; LR: likelihood ratio.