Association of baseline neutrophil extracellular trap (NET) levels with demographic characteristics, comorbidities and clinical variables
| Adjusted (multivariate) linear regression coefficient (95% CI) | p-value | |
| General characteristics | ||
| Age at study entry | −0.001 (−0.02–0.006) | 0.292 |
| Male | 0.118 (−0.22–0.463) | 0.502 |
| BMI | −0.001 (−0.03–0.026) | 0.892 |
| Ever-smoker | 0.147 (−0.23–0.529) | 0.450 |
| Pack-years (per 10 years) | −0.05 (−0.10– −0.00) | 0.042 |
| Comorbidities | ||
| Diabetes mellitus | 0.160 (−0.23–0.559) | 0.428 |
| Insulin treatment | 0.318 (−0.25–0.895) | 0.279 |
| COPD | −0.01 (−0.42–0.395) | 0.943 |
| Asthma | −0.24 (−0.99–0.504) | 0.522 |
| Heart failure | −0.46 (−0.89– −0.02) | 0.036 |
| Hypertension | 0.041 (−0.28–0.370) | 0.802 |
| Cerebrovascular disease | −0.23 (−0.79–0.326) | 0.410 |
| Peripheral artery occlusive disease | −0.26 (−0.93–0.409) | 0.442 |
| Renal insufficiency | −0.04 (−0.38–0.290) | 0.775 |
| Neoplastic disease | −0.36 (−1.0–0.283) | 0.270 |
| Clinical variables | ||
| Steroid pre-treatment | 0.327 (−0.41–1.07) | 0.385 |
| Antibiotic pre-treatment | −0.02 (−0.40–0.355) | 0.891 |
| Days with symptoms | 0.004 (−0.01–0.021) | 0.648 |
| Temperature | −0.01 (−0.18–0.164) | 0.902 |
| Oxygen saturation | 0.006 (−0.04–0.056) | 0.790 |
| PSI score | 0.001 (−0.001–0.007) | 0.886 |
| Positive blood culture | 0.115 (−0.38–0.615) | 0.649 |
| Pathogen detection | −0.05 (−0.41–0.312) | 0.782 |
| Neutrophil granulocytes | 0.033 (0.006–0.061) | 0.016 |
| Leukocyte count | 0.019 (−0.00–0.043) | 0.116 |
Baseline NET levels were negatively associated with the quantity of pack-years and a history of heart failure, but positively associated with counts of neutrophils. p<0.05 statistically significant. BMI: body mass index; COPD: chronic obstructive pulmonary disease; PSI: Pneumonia Severity Index.