Variable | n | p-value | Pearson's R |
Univariate analysis | |||
Age | 71 | 0.016 | 0.286 |
Duration of systemic sclerosis | 70 | 0.954 | 0.007 |
WHO functional class | 70 | 0.485 | 0.084 |
Lung function | |||
FVC | 69 | 0.051 | −0.236 |
FEV1 | 69 | 0.017 | −0.286 |
FEV1 % | 70 | 0.057 | −0.229 |
DLCO % | 71 | 0.025 | −0.265 |
KCO % | 69 | 0.028 | −0.265 |
NT-proBNP | 69 | 755 | 38 |
6MWD | 66 | 0.097 | 0.206 |
Echocardiography | |||
IVC | 58 | 0.04 | 0.271 |
Right atrial area | 64 | 0.167 | 0.175 |
Right ventricular area | 63 | 0.828 | 0.028 |
TRV | 66 | 0.003 | 0.360 |
sPAP | 65 | 0.004 | 0.351 |
Right heart catheterisation | |||
mPAP | 71 | 0.001 | 0.402 |
TPG | 71 | <0.001 | 0.430 |
PVR | 71 | <0.001 | −0.456 |
Multivariate analysis with centre as fixed factor | |||
Including invasive haemodynamic PVR | 56 | 0.002 | 0.460 |
Only noninvasive parameters | |||
Model 1 TRV | 56 | 0.003 | 0.439 |
Model 2 + KCO % | 56 | 0.046 | 0.512 |
Model 3 + IVC | 56 | 0.02 | 0.577 |
WHO: World Health Organization; FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s; DLCO: diffusing capacity of the lung for carbon monoxide; KCO: transfer coefficient of the lung for carbon monoxide; NT-proBNP: N-terminal pro--brain natriuretic peptide; 6MWD: 6-min walking distance; IVC: inferior vena cava; TRV: tricuspid regurgitation velocity; sPAP: systolic pulmonary arterial pressure; mPAP: mean pulmonary arterial pressure; TPG: transpulmonary gradient; PVR: pulmonary vascular resistance.