Control | CF | p-value | |
Free NE activity µg·mL−1 | 0.01 (0.01–0.02) | 23.4 (15.2–50.1) | <0.001 |
Surface-bound NE activity D/A ratio | 0.09 (0.04–0.12) | 0.80 (0.56–1.07) | <0.001 |
MPO µg·mL−1 | 0.4 (0.3–0.6) | 29.7 (18.4–51.8) | <0.001 |
SLPI ng·mL−1 | 1211.5 (923.3–1811.7) | 180.8 (87.3–474.1) | <0.001 |
AAT–NE ng·mL−1 | 24.8 (15.6–33.2) | 82.6 (40.4–183.1) | <0.001 |
IL-8 ng·mL−1 | 0.6 (0.3–0.8) | 11.2 (8.2–16.6) | <0.001 |
Data are presented as median (interquartile range), unless otherwise stated. NE: neutrophil elastase; D/A: donor/acceptor fluorescence; MPO: myeloperoxidase; SLPI: secretory leukocyte protease inhibitor; AAT–NE: α1-antitrypsin–NE complexes.