TABLE 3

Association between visuo-construction performance (VCP) and air pollution at baseline, average lung function and the interaction between air pollution and lung function

Exposureβ-estimatep-value
Air pollution
 PM10−0.25 (−0.40; −0.11)0.001
 PM2.5−0.21 (−0.36; −0.06)0.005
 NO2−0.26 (−0.50; −0.03)0.030
Lung function
 FEV10.18 (0.02; 0.34)0.030
 FVC0.23 (0.07; 0.39)0.005
 FEV1/FVC−0.04 (−0.20; 0.11)0.566
Air pollution × lung function
 PM10 × FEV1−0.05 (−0.15; 0.06)0.381
 PM2.5 × FEV1−0.07 (−0.18; 0.04)0.213
 NO2 × FEV1−0.10 (−0.26; 0.05)0.185
 PM10 × FVC−0.08 (−0.20; 0.03)0.142
 PM2.5 × FVC−0.10 (−0.22; 0.02)0.090
 NO2 × FVC−0.18 (−0.35; −0.01)0.035
 PM10 × FEV1/FVC0.10 (−0.03; 0.23)0.123
 PM2.5 × FEV1/FVC0.09 (−0.05; 0.23)0.208
 NO2 × FEV1/FVC0.16 (−0.05; 0.36)0.130

The total number of subjects is 520. Average lung function between baseline and follow-up examinations. VCP was measured at follow-up examination. Linear regression coefficients (β) with corresponding 95% confidence intervals were estimated for increases of one interquartile range in air pollution or in the respective lung function parameter. All models were adjusted for age, height, body mass index, socio-economic status, current and former smoking habits, exposure to second-hand smoke, living in an urban area versus a rural area, APOE-ε4 incidence, physical activity and depression. PMx: particles with a 50% cut-off aerodynamic diameter of x µm; NO2: nitrogen dioxide; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity.