Patient characteristics at baseline in intention-to-treat populations
| First author [ref.] | Mean age years | Male % | Symptoms (health status) | Lung function (mean post-BD FEV1 % pred) | Exacerbation history in prior 12 months | Current smoker % | Comorbidities |
| Vestbo [20] | 67 | 51 | Mean CAT 21.7; CAT ≥10 90% | 61 | Mean 2.01; 49% ≥2 moderate/severe; 7% ≥1 severe; 19% no history | 46 | Any: 77%; vascular: 49%; hypertension: 48%; cardiac: 26%; cardiovascular risk factors: 52%; diabetes: 16%; asthma: 22% |
| Sharafkhaneh [23] | 63–64 | 62 | Mean mMRC 3; mean SGRQ 56–59 (calculated CAT 22.4–23.6) | 38 | 41% ≥2 moderate | 36 | Not reported |
| Wedzicha [24] | 64–65 | 69 | Mean SGRQ 48 (calculated CAT 19.2) | 42 | Mean 1.5 | 39 | Not reported |
| Dransfield [6] | 64 | 57 | CAT and SGRQ not collected | 45 | Mean 1.6–1.7; 39% ≥2 moderate/severe; 20% ≥1 severe | 44 | Any 62%; cardiac 10%; hypertension 45%; diabetes 12% |
| Wedzicha [7] | 63 | 75 | Mean SGRQ 52–53 (calculated CAT 20.8–21.2) | 37 | 22% ≥2 moderate | 38 | Cardiovascular disease 4%; cardiovascular risk factors 88%; hypertension 47%; diabetes 10% |
| Wedzicha [8] | 65 | 76 | Mean CAT 17; mMRC 2/3/4 72%/26%/2%; mean SGRQ 47 | 44 | 19% ≥2 moderate | 40 | Cardiovascular history/condition 9%; hypertension 48%; diabetes 12%; body mass index >30 kg·m–2 20% |
| Vestbo [25] | 63 | 76 | Mean CAT 22 | 37 | Mean 1.2–1.3 | 48 | Any 84%; cardiac 40–43%; hypertension 56%; diabetes 10%; obesity 5% |
BD: bronchodilator; FEV1: forced expiratory volume in 1 s; CAT: COPD Assessment Test; mMRC: modified Medical Research Council Dyspnoea scale; SGRQ: St George's Respiratory Questionnaire.