TABLE 1

Baseline characteristics, conditions and clinical outcomes, and their associated cytomegalovirus (CMV) PCR results in bronchoalveolar lavage

VariableNegative CMV (n=98)Positive CMV (n=35)p-value
Demographic
 Age years (median (IQR))62.0 (23.0)61.0 (24.0)0.37
 Men63 (64)23 (66)0.88
 Current smoker31 (36)7 (25)0.28
 Current alcohol consumer8 (10)2 (7)>0.99
Immunocompromised#47 (48)25 (71)0.017
 HIV8 (8)3 (9)>0.99
 Transplant19 (19)9 (26)0.43
 Cancer16 (16)7 (20)0.62
 Systemic corticosteroids21 (21)17 (49)0.002
Diagnosis at ICU admission0.73
 Respiratory failure59 (60)24 (69)
 Septic shock18 (18)5 (14)
 Cardiac failure9 (9)2 (6)
 Sepsis5 (5)1 (3)
 Other7 (7)3 (9)
Previous antibiotic7 (7)3 (9)0.72
Comorbidities+76 (78)26 (74)0.70
 Chronic respiratory disease27 (28)8 (23)0.55
 Chronic cardiovascular disease23 (24)6 (17)0.44
 Diabetes mellitus12 (12)6 (17)0.57
 Neurological disease11 (11)7 (20)0.25
 Chronic renal disease12 (12)7 (20)0.27
 Chronic liver disease4 (4)2 (6)0.65
 Arterial hypertension38 (39)18 (51)0.19
Laboratory tests (median (IQR))
 Creatinine mg·mL−11.0 (1.0)1.2 (1.1)0.98
 C-reactive protein mg·dL−112.5 (15.9)11.9 (20.0)0.87
 White blood-cell count 109·L−110.0 (9.0)9.0 (12.0)0.41
SOFA score at ICU admission (median (IQR))5 (6)5 (5)0.91
Outcomes
 Pulmonary complications16 (39)5 (33)0.70
 NIMV59 (94)17 (94)>0.99
 IMV72 (92)26 (93)>0.99
 Hospital stay days (median (IQR))35.0 (33.0)46.0 (62.0)0.017
 ICU stay days (median (IQR))19.5 (21.5)31.5 (69.0)0.070
 30-day mortality38 (41)21 (64)0.024

Data are presented as n (%) unless otherwise stated. Values in bold are for when p<0.05. IQR: interquartile range; ICU: intensive care unit; SOFA: sepsis-related organ failure assessment; NIMV: noninvasive mechanical ventilation; IMV: invasive mechanical ventilation. #: subjects may have more than one immunocompromising condition; : daily doses >20 mg prednisolone-equivalent for more than 2 weeks in the month previous to admission; +: subjects may have more than one comorbid condition.