TABLE 2

Differences between patients with chronic Pseudomonas aeruginosa infection, chronic infection by other pathogens and no chronic infection

P. aeruginosa chronic infectionOther pathogen chronic infectionNo chronic infectionp-value
Patients389 (15.0%)918 (35.4%)1289 (49.7%)
Demographics
 Age years70 (59–77)67 (57–74)66 (57–75)<0.001
 ≥65 years old244 (62.7%)685 (74.6%)674 (52.3%)<0.001
 Male167 (42.9%)522 (41.7%)468 (36.3%)<0.001
 BMI kg·m−224.9 (21.3–27.7)24.6 (21.4–27.7)25.2 (22.3–28.4)<0.001
 Smokers and ex-smokers122 (31.4%)457 (49.8%)516 (40.0%)<0.001
Comorbidities
 Ischaemic heart disease64 (16.5%)251 (20.0%)190 (14.7%)<0.001
 Stroke30 (7.7%)79 (6.3%)69 (5.4%)0.009
 Diabetes53 (13.6%)115 (9.2%)137 (10.6%)0.18
 Chronic renal failure23 (5.9%)61 (4.9%)88 (6.8%)0.82
 COPD78 (20.1%)196 (15.7%)229 (17.8%)0.10
 Haematological malignancy9 (2.3%)22 (1.8%)11 (0.9%)0.009
 Solid tumour27 (6.9%)88 (7.0%)71 (5.5%)0.001
Functional status
 FEV1 % predicted57.9 (42–77.7)69.2 (50–89.8)77.0 (59–95)<0.001
 FEV1 <50% predicted135 (34.7%)290 (31.6%)200 (15.5%)<0.001
Clinical status
 Exacerbations in the previous year3 (2–4)2 (1–3)1 (0–2)<0.001
 At least one hospitalisation in the previous year233 (59.9%)400 (31.9%)227 (17.6%)<0.001
Disease severity
 BSI score13 (10–17)8 (5–13)5 (3–8)<0.001
 Mild BSI score#0 (0%)209 (22.8%)543 (42.1%)<0.001
 Moderate BSI score54 (13.9%)461 (50.2%)458 (35.5%)<0.001
 Severe BSI score+335 (86.1%)581 (63.3%)288 (22.3%)<0.001
Quality of life
 SGRQ58.7 (42.0–79.3)§44.5 (26.8–62.6)ƒ35.6 (21.0–52.3)##<0.001

Data are presented as median (interquartile range) unless otherwise stated. BMI: body mass index; COPD: chronic obstructive pulmonary disease; FEV1: forced expiratory volume in 1 s; BSI: Bronchiectasis Severity Index; SGRQ: St George's Respiratory Questionnaire. #: BSI 0–4; : BSI 5–8; +: BSI >9; §: n=125; ƒ: n=517; ##: n=345.