TABLE 2

Relationship between first and second trimester fetal size and dispensed asthma and eczema medications at 15 years of age

First trimester CRL z-scoreSecond trimester BPD z-scoreSecond trimester femur length z-score
Asthma
 Asthma prescriptions−0.186±1.06
(n=111)
−0.002±1.00
(n=146)
−0.081±1.03
(n=145)
 No asthma prescriptions0.024±0.99
(n=954)
−0.008±0.98
(n=1320)
0.013±0.97
(n=1315)
 OR# (95% CI) for asthma (for  1 sd decrease in z-score)1.26 (1.03–1.54)0.99 (0.83–1.19)1.10 (0.92–1.32)
Eczema
 Eczema prescriptions0.011±0.92
(n=85)
0.054±1.03
(n=111)
0.044±1.17
(n=111)
 No eczema prescriptions0.002±1.00
(n=980)
−0.013±0.98
(n=1355)
0.0008±0.96
(n=1349)
 OR# (95% CI) for eczema (for  1 sd decrease in z-score)1.01 (0.81–1.27)0.93 (0.76–1.14)0.96 (0.78–1.17)

Data are presented as mean±sd, unless otherwise stated. Gestation and sex were included in the calculation of z-scores, but not included in the logistic model. CRL: crown–rump length; BPD: biparietal diameter. #: logistic regression adjusted for maternal smoking during pregnancy and maternal history of asthma; : p=0.027.