Variables | Main multivariate model# | Second multivariate model¶ | Third multivariate model+ | ||||||
Hazard ratio (95% CI) | p-value | Score value | Hazard ratio (95% CI) | p-value | Score value | Hazard ratio (95% CI) | p-value | Score value | |
Age years | |||||||||
<50 | Reference | 0.008 | Reference | 0.007 | Reference | 0.02 | |||
50–65 | 3.65 (1.33–9.99) | +2 | 2.95 (1.07–8.14) | +2 | 2.80 (1.01–7.75) | +2 | |||
>65 | 4.70 (1.78–12.4) | +3 | 4.49 (1.73–11.70) | +3 | 3.73 (1.43–9.77) | +3 | |||
Previous cancer (resolved >2 years) | 1.66 (0.56–4.91) | 0.36 | 1.82 (0.61–5.38) | 0.28 | 2.05 (0.70–6.02) | 0.19 | |||
Chronic inflammatory disease | 2.03 (0.69–5.94) | 0.20 | 1.95 (0.66–5.73) | 0.23 | 2.05 (0.70–5.99) | 0.19 | |||
Unfractionated heparin | 1.58 (0.84–2.98) | 0.15 | 1.29 (0.65–2.57) | 0.47 | 1.23 (0.63–2.39) | 0.54 | |||
RVD at diagnosis | 1.08 (0.59–1.96) | 0.81 | 0.86 (0.46–1.62) | 0.65 | 0.87 (0.48–1.59) | 0.66 | |||
PVOI | |||||||||
Model 1: PVOI at inclusion ≥5% (over PVOI at inclusion <5%)# | 2.06 (1.14–3.72) | 0.016 | +2 | ||||||
Model 2: PVOI at diagnosis ≥40% (over PVOI at diagnosis <40%)¶ | 2.36 (1.34–4.17) | 0.003 | +2 | ||||||
Model 3: PVOI at diagnosis ≥40% and/or PVOI at inclusion ≥5% (over PVOI at diagnosis <40% and PVOI at inclusion <5%)+ | 4.73 (1.99–11.2) | 0.0004 | +3 | ||||||
Residual DVT at inclusion | 1.72 (0.92–3.23) | 0.09 | 1.60 (0.85–3.01) | 0.14 | 1.70 (0.90–3.22) | 0.10 | |||
D-dimer <250 μg·L−1 | 1.49 (0.79–2.80) | 0.21 | 1.53 (0.81–2.88) | 0.19 | 1.74 (0.92–3.28) | 0.09 | |||
Antiphospholipid antibodies (lupus anticoagulant and/or anticardiolipin antibodies) | 2.38 (1.15–4.89) | 0.01 | +2 | 2.64 (1.32–5.28) | 0.006 | +2 | 2.57 (1.29–5.11) | 0.007 | +2 |
Elevated Factor VIII (90th percentile) | 1.07 (0.48–2.40) | 0.86 | 1.08 (0.48–2.43) | 0.86 | 0.91 (0.41–2.06) | 0.83 |
RVD: right ventricular dysfunction; PVOI: pulmonary vascular obstruction index; DVT: deep vein thrombosis. #: main model: estimate of PVOI at pulmonary embolism diagnosis was not included (Harrell's C index including three significant variables was 0.66 (observed score) and 0.68 after bootstrapping); ¶: second model: estimate of PVOI at inclusion was excluded (Harrell's C index including three significant variables was 0.66 (observed score) and 0.68 after bootstrapping); +: third model: PVOI at pulmonary embolism diagnosis and at inclusion were combined into one variable with two categories (Harrell's C index including three significant variables was 0.63 (observed score) and 0.65 after bootstrapping).