Changes from baseline at 6 and 12 months, and 2 years after coil treatment
| Overall group | Patients who attended the 2-year follow-up visit | ||||||
| Baseline | 6 months | 12 months | Baseline | 6 months | 12 months | 2 years | |
| Subjects n | 50 | 47 | 44 | 32 | 32 | 32 | 32 |
| 6MWT m | 300±112 | +18±81; p=0.14 | −2±87; p=0.88 | 323±105 | +25±67; p=0.048 | +15±77; p=0.29 | +6±84; p=0.56 |
| ≥54 m | 16/44 (36%) | 8/43 (19%) | 12/32 (38%) | 7/32 (22%) | 7/28 (25%) | ||
| ≥25 m | 19/44 (43%) | 12/43 (28%) | 15/32 (47%) | 11/32 (34%) | 11/28 (39%) | ||
| mMRC scale | 3±0.7 | −0.5±0.9; p=0.0002 | −0.5±1; p=0.006 | 2.9±0.6 | −0.7±0.9; p=0.0003 | −0.7±1; p=0.0007 | −0.4±1; p=0.06 |
| ≥1 | 19/47 (40%) | 19/41 (46%) | 15/32 (47%) | 15/30 (50%) | 13/30 (43%) | ||
| FEV1 L | 0.75±0.25 | +0.05±0.14; p=0.02 | +0.04±0.15; p=0.1 | 0.78±0.26 | +0.04±0.15; p=0.15 | +0.03±0.14; p=0.21 | 0±0.16; p=0.92 |
| ≥100 mL | 17/47 (36%) | 12/44 (27%) | 12/32 (38%) | 8/32 (25%) | 8/32 (25%) | ||
| ≥10% | 21/47 (45%) | 14/44 (32%) | 14/32 (44%) | 9/32 (28%) | 12/32 (38%) | ||
| RV L | 6.2±0.86 | −0.53±0.72; p<0.0001 | −0.47±0.68; p<0.0001 | 5.92±0.74 | −0.46±0.51; p<0.0001 | −0.39±0.68; p=0.003 | −0.28±0.69; p=0.03 |
| ≥350 mL | 29/47 (62%) | 25/44 (57%) | 19/32 (59%) | 18/32 (56%) | 14/32 (44%) | ||
| SGRQ (0–100) | 60.8±12.8 | −11.1±16.1; p<0.0001 | −9.1±15.9; p=0.0006 | 57.9±12.3 | −12.3±17.6; p=0.0005 | −11.5±16.4; p=0.0006 | −7.9±14.5; p=0.005 |
| ≥4 points | 32/45 (71%) | 26/42 (62%) | 24/31 (77%) | 21/30 (70%) | 20/31 (65%) | ||
| ≥8 points | 28/45 (62%) | 21/42 (50%) | 21/31 (68%) | 16/30 (53%) | 16/31 (52%) | ||
Data are presented as mean±sd or number (%), unless otherwise stated. The percentage of patients reaching the minimal clinically important difference for each variable is indicated. Changes from baseline were assessed by paired t-tests. 6MWT: 6-min walking test; mMRC : modified Medical Research Council dyspnoea scale; FEV1: forced expiratory volume 1 s; RV: residual volume; SGRQ: Saint George's Respiratory Questionnaire.