Date | December 2013 | March 2014 | December 2014 to September 2015 | December 2016 |
Events | Pregnancy | |||
Treatment | None | Amlodipine 20 mg once daily | Amlodipine 20 mg once daily | Sildenafil 20 mg three times daily, bosentan 125 mg twice daily, amlodipine 20 mg once daily |
mPAP mmHg | 52 | 28 | 56 | |
mPAP with NO mmHg | 27 | 21 | 51 | |
CO L·min−1 | 3.9 | 5.1 | 3.8 | |
CI L·min−1·m−2 | 2.5 | 3.3 | 2.4 | |
PVR Wood units | 11.5 | 3.9 | 12.1 | |
RV size and function | Severely dilated, mildly impaired systolic function | Normal size, normal systolic function | Moderate-severely dilated, severely impaired function | |
BNP pg·mL−1 | 607 | 71 | 775 |
mPAP: mean pulmonary arterial pressure; CO: cardiac output; CI: cardiac index; PVR: pulmonary vascular resistance; RV: right ventricular; BNP: brain natriuretic peptide.